J Korean Neuropsychiatr Assoc.
2007 May;46(3):254-261.
Correlation between Head Circumference and Cognition in the Elderly by ApoE Genotype
- Affiliations
-
- 1Department of Psychiatry, ,Yonsei University College of Medicine, Seoul, Korea.
- 2Institute of Behavioral Science in Medicine,Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Psychiatry, College of Medicine, Seoul National University, Boramae Hospital, Seoul, Korea.
- 4Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon, Korea.
- 5Department of Social and Preventive Medicine, School of Medicine, Sunghkyunkwan University, Suwon, Korea.
- 6Department of Neuropsychiatry, College of Medicine, Inje University, Sanggye Paik Hospital, Seoul, Korea.
- 7Department of Psychiatry, Ajou University School of Medicine, Suwon, Korea. antiaging@ajou.ac.kr
Abstract
OBJECTIVES
The aim of this study is to find out the effect of ApoE genotype on correlation between head circumference and cognition of the elderly in the community.
METHODS
A total of 1,152 subjects (380 men and 772 women) aged 60-91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history and K-MMSE (Korean version-Mini Mental State Examination). We also measured the head circumference and examined ApoE genotype.
RESULTS
On regression analysis, as head circumference becomes smaller, K-MMSE scores decreased adjusted by age, sex, educational level, ApoE epsilon4 allele, current smoking and alcohol drinking status (beta=0.15, p=0.04). Only in the lowest quartile group, presence of ApoE epsilon4 allele reduced K-MMSE scores adjusted by age, sex, educational level, height, current alcohol drinking and smoking status (beta=-1.39, p=0.008).
CONCLUSION
These results suggest that head circumference may have an influence on K-MMSE scores, and presence of ApoE epsilon4 allele may be a medicating factor.
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