J Korean Neuropsychiatr Assoc.
2006 Jul;45(4):349-356.
Correlation between Metabolic Syndrome and Cognition in the Elderly
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Yonsei University, Seoul, Korea. drobh@chollian.net
- 2Institution of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 3Yonsei University Research Institute of Science for Aging, Seoul, Korea.
- 4Center for Occupational Disease Research, Occupational Safety and Health Research Institute, Incheon, Korea.
- 5Department of Social and Preventive Medicine, School of Medicine, Sungkyunkwan University, Suwon, Korea.
- 6Department of Neuropsychiatry, College of Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.
Abstract
OBJECTIVE
The purpose of this study is to find out the effect of ApoE genotype in correlation between metabolic syndrome and cognition of the elderly in the community.
METHODS
A total of 1,305 subjects (440 men and 865 women) aged 60-98 years were analyzed from preliminary data of Gwangju Dementia and MCI Study (GDEMCIS). The metabolic syndrome was assessed as defined by the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, family history of dementia and stroke, and Korean version-Mini Mental State Examination (K-MMSE). We also examined ApoE genotype and analyzed associated factors with metabolic syndrome.
RESULTS
These Metabolic syndrome was present in 28.6% of the subjects (13.4% of men and 36.3% of women). On multiple logistic regression analysis, low serum HDL cholesterol was associated with an increased risk for cognitive impairment (K-MMSE score < or = 17) adjusted by age, sex, educational level, and smoking in the presence of ApoE epsilon4 allele (OR 0.95, 95% CI 0.92-0.99).
CONCLUSION
These results suggest that serum HDL cholesterol may affect cognitive function in the elderly in the presence of ApoE epsilon4 allele.
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