J Korean Neuropsychiatr Assoc.  2002 Jul;41(4):725-732.

A Female Case of Kleine-Levin Syndrome Treated with Amantadine

Affiliations
  • 1Department of Psychiatry, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea.
  • 2Department of Psychiatry, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

Abstract

Kleine-Levin syndrome is a rare disorder which usually affects adolescent males and is characterized by periodic hypersomnia, hyperphagia and abnormal behavior. This is an unexplained clinical syndrome for which several etiologies have been entertained with no standard treatment is yet available. A 18-year old woman began suffering from recurrent hypersomnia, hyperphagia, and behavioral disturbances such as irritability, derealization, and amnesia. She was normal between the episodes and diagnosed as Kleine-Levin syndrome. In the course of about two years she had 11 episodes and the mean interval between the episodes was 52.8+/-16.7 days. After application of amantadine, there were two mild episodes and then she had no episodes for more than 6 months. This case suggests the possible role of amantadine in the treatment of Kleine-Levin syndrome.

Keyword

Kleine-Levin syndrome; Recurrent hypersomnia; Amantadine

MeSH Terms

Adolescent
Amantadine*
Amnesia
Depersonalization
Disorders of Excessive Somnolence
Female*
Humans
Hyperphagia
Kleine-Levin Syndrome*
Male
Amantadine
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