J Korean Neuropsychiatr Assoc.
2000 Mar;39(2):445-455.
Antidepressant Effects of Ethaverine, a Calcium Channel Antagonist, in Animal Models of Depression
- Affiliations
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- 1Department of Neuropsychiatry, School of Medicine, and Institute of Neuroscience, Inje University, Pusan Paik Hospital, Pusan, Korea.
- 2Department of Neuropsychiatry, Masan Dong-Seo Hospital, Masan, Korea.
- 3Department of Life science, Pohang University of Science and Technology, Pohang, Korea.
Abstract
OBJECTIVES
This pre-clinical study was performed to assess the effects of ethaverine in the two kinds of behavioral models of depression in rats.
METHODS
We observed the changes of the immobility time in the forced swimming test and the quantity of sucrose consumed in the chronic mild stress model, using ethaverine(20mg/kg) alone, imipramine(20mg/kg) alone, or ethaverine and imipramine concomitantly.
RESULTS
In the forced swimming test, both single treatment and chronic treatment(for 7 days) with imipramine or ethaverine significantly reduced the immobility time, and concomitant chronic treatment with ethaverine potentiated the effect of imipramine. In the chronic mild stress model, both imipramine and ethaverine reversed the decreased sucrose consumption induced by 3-week stress and concomitantly treated ethaverine potentiated the effect of imipramine in the early phase of treatment.
CONCLUSIONS
The data suggest that ethaverine can be used alone or concomitantly with other anti-depressants in the clinical situation.
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