J Korean Geriatr Soc.
2006 Sep;10(3):177-185.
Effect of ApoE Genotype on the Relationship between Nutritional Risk and Cognition in the Elderly
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Yonsei University College of Medicine, Korea. drobh@chollian.net
- 2Institution of Behavioral Science in Medicine, Yonsei University College of Medicine, Korea.
- 3Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Korea.
- 4Center for Occupational Disease Research, Occupational Safety and Health Research Institute, Korea.
- 5Severance Mental Health Hospital, Yonsei University College of Medicine, Korea.
Abstract
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BACKGROUND: The purpose of this study is to find out the effect of ApoE genotype on the relationship between nutritional risk and cognition of the elderly in a community.
METHODS
A total of 996 subjects (343 men and 653 women) aged 60~91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, K-SGDS (Korean version of Short Form Geriatric Depression Scale), K-MMSE (Korean version-Mini Mental State Examina- tion), and NSI (Nutritional Screening Initiative) checklist. We also examined blood pressure, fasting serum glucose, lipid profile, body mass index, and ApoE genotyping.
RESULTS
649 subjects (65.2%) were on good nutritional state (NSI score < or = 2) and 347 subjects (34.8%) were on moderate or high nutritional risk (NSI score > or = 3). On multiple logistic regression analysis, moderate or high nutritional risk was associated with an increa- sed risk for cognitive impairment (K-MMSE score < or = 17) after adjustment with age, sex, K-GDS and educational level in the absence of ApoE epsilon4 allele (OR 1.78, 95% CI 1.15-2.77).
CONCLUSION
These results suggest that nutritional risk may be associated with cognitive function in the elderly only in the absence of ApoE epsilon4 allele.
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