J Korean Ophthalmol Soc.  2013 Oct;54(10):1534-1539.

Incidence of New Choroidal Neovascularization in Fellow Eyes of Patients Treated for Age-Related Macular Degeneration

  • 1Myung-Gok Eye Research Institute, Department of Ophthalmology, Kim's Eye Hospital, Konyang University, Seoul, Korea. yjlew@kimeye.com


To investigate the development of new choroidal neovascularization in fellow eyes of patients treated for unilateral exudative age-related macular degeneration (AMD).
Three hundred fourteen patients who were first diagnosed with unilateral exudative AMD and treated with intravitreal bevacizumab or ranibizumab were studied retrospectively.
New exudative AMD developed in 7.0% of fellow eyes after 1 year, 10.8% after 2 years and 13.7% after more than 2 years. According to the subtype of exudative AMD, there were no significant differences between classic CNV, occult or minimally classic CNV, and PCV in the incidence of new exudative AMD. After 2 years, a higher conversion rate was found in the bevacizumab-treated group than the ranibizumab-treated group.
The cumulative incidence of involvement in fellow eyes with exudative AMD was 13.7% over 2 years.


Bevacizumab; Exudative age-related macular degeneration; Incidence; Ranibizumab

MeSH Terms

Antibodies, Monoclonal, Humanized
Choroidal Neovascularization*
Macular Degeneration*
Antibodies, Monoclonal, Humanized


  • Figure 1. Incidence of new neovascular AMD in the fellow eye.

  • Figure 2. Fundus photograph and fluorescein angiograph of the right eye of a 64 year old female (A, B, C); left eye (D, E, F). (A, B, C) No specific abnormality (D) Choroidal neovascular membrane (CNVM) of the macula with retinal hemorrhage. (E) Predominant classic choroidal neovascularizaion with well demarcated lesion 23 seconds after injection. (F) Late phase shows staining implying old lesions. She was treated with intravitreal Ranibizumab injection 3 times.

  • Figure 3. Fundus photograph and fluorescein angiograph of same patient with figure 2 after 2 months of right visual disturbance. Right eye (A, B, C) and left eye (D, E, F). (A) New hemorrhagic spot around macula (B, C) Class choroidal neovascularization which was absent 2 months prior (D) Retinal hemorrhage was decreased with fibrotic tissue changes. (E, F) Scar change with staining.



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