J Korean Ophthalmol Soc.  2012 Apr;53(4):522-527.

Intravitreal Bevacizumab for Macular Edema Secondary to Ruptured Retinal Arterial Macroaneurysm

• Moon SJ
• Kim SW
• Kim HS
• Kang JH
• Yoon HS

Abstract

PURPOSE
To study the short-term effect of intravitreal injection of bevacizumab in the treatment of macular edema secondary to retinal macroaneurysm.
METHODS
Eight eyes of 9 patients who underwent consecutive intravitreal bevacizumab injections for macular edema secondary to retinal macroaneurysm were prospectively evaluated. Complete eye examination including the best corrected visual acuity (BCVA), fundus examination and optical coherence tomography (OCT) were performed at baseline and follow-up visits at 2, 4 and 6 months.
RESULTS
The mean age was 73.6 +/- 6.9 years, and the mean study period was 7.3 +/- 2.6 months. At the final visit, BCVA improved from log MAR 1.92 +/- 0.67 to log MAR 0.87 +/- 0.57. The mean central macular thickness on OCT image decreased from 388 +/- 168 microm at the initial visit to 200 +/- 39 microm at the final visit. Three eyes without subretinal hemorrhage presented better visual outcome than eyes with subretinal hemorrhage. All eyes showed some decrease in angiographic leakage. No adverse side effects were observed following the injections.
CONCLUSIONS
Intravitreal bevacizumab injection can be used as a selective alternative treatment modality for macular edema secondary to retinal macroaneurysm.

Keyword

Bevacizumab; Retinal macroaneurysm

MeSH Terms

Antibodies, Monoclonal, Humanized
Eye
Follow-Up Studies
Hemorrhage
Humans
Intravitreal Injections
Macular Edema
Prospective Studies
Retinaldehyde
Tomography, Optical Coherence
Visual Acuity
Bevacizumab
Antibodies, Monoclonal, Humanized
Retinaldehyde

Figure

• 

  Figure 1 (A) The fundus photograph of case 1 at pre-injection of bevacizumab shows the edematous macula, retinal and subretinal hemorrhage, exudates at the posterior pole, associated a macroaneurysm in the supratemporal artery in his right eye. (B) The optical coherence tomography (OCT) image at pre-injection demonstrated a lot of subretinal serous fluid. (C, D) The fundus photograph and OCT image at 4 months after bevacizumab injection showed subretinal serous fluid, preretinal and subretinal hemorrhage were absorbed completely and small retinal hard exudates increased slightly.

• 

  Figure 2 (A, B) At pre-injection, the fundus photograph and optical coherence image of case 3 demonstrats mild, superficial retinal hemorrhages are situated along a ruptured arterial macroaneurysm and macula was edematous with serous subretinal fluid collection. (C, D) The images at 2 months after bevacizumab treatment shows retinal hemorrhage and macula edema were improved, but some exudates are seen at macular area.

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