Korean J Ophthalmol.  2019 Apr;33(2):198-199. 10.3341/kjo.2018.0079.

Macular Hole Formation after Intravitreal Injection of Bevacizumab for Diabetic Macular Edema

• Lee YJ
• Kim M

• KMID: 2442626
• DOI: http://doi.org/10.3341/kjo.2018.0079

Abstract

No abstract available.

MeSH Terms

Bevacizumab*
Intravitreal Injections*
Macular Edema*
Retinal Perforations*
Bevacizumab

Figure

• 

  Fig. 1 Ocular findings at initial presentation. (A) Fundus examination showed a few retinal hemorrhages. (B) Fluorescein angiography revealed a diffuse petaloid pattern of leakage around the central fovea. Serial changes in optical coherence tomography (OCT) image. (C) Before treatment, OCT revealed a thin epiretinal membrane, serous macular detachment, and intraretinal edema that was located at the outer retina. (D) Two weeks after the injection of bevacizumab, OCT showed the formation of a full thickness macular hole and decreasing intraretinal edema. (E) One month after vitrectomy, the macular hole was closed, but the serous macular detachment remained. (F) Six months after vitrectomy, the serous macular detachment remained unchanged

Reference

1. Querques G, Souied EH, Soubrane G. Macular hole following intravitreal ranibizumab injection for choroidal neovascular membrane caused by age-related macular degeneration. Acta Ophthalmol. 2009; 87:235–237.

2. Raiji VR, Eliott D, Sadda SR. Macular hole overlying pigment epithelial detachment after intravitreal injection with ranibizumab. Retin Cases Brief Rep. 2013; 7:91–94.

3. Grigoropoulos V, Emfietzoglou J, Nikolaidis P, et al. Full-thickness macular hole after intravitreal injection of ranibizumab in a patient with retinal pigment epithelium detachment and tear. Eur J Ophthalmol. 2010; 20:469–472.

4. Kim M, Lee P, Kim Y, et al. Effect of intravitreal bevacizumab based on optical coherence tomography patterns of diabetic macular edema. Ophthalmologica. 2011; 226:138–144.