J Korean Ophthalmol Soc.  2012 Feb;53(2):342-347.

Moxifloxacin Mixed Augmented Amniotic Membrane Transplantation for Perforating Infectious Keratitis

• Kim HK

Abstract

PURPOSE
To report the clinical results of moxifloxacin mixed augmented amniotic membrane transplantation (AMT) in 2 patients with perforating infectious keratitis.
CASE SUMMARY
Moxifloxacin mixed augmented amniotic membrane transplantations were performed in 2 patients with rapidly deteriorating deep perforated bacterial keratitis. All patients preserved their eyesight. Complete re-epithelization over the amniotic membrane were observed within a month. The corneal surfaces were healed with opacity, and there were no active infectious infiltrations or recurrences for 3 months after application.
CONCLUSIONS
Moxifloxacin mixed augmented AMT has proven to be successful both tectonically and physiologically for cases with perforating active bacterial keratitis.

Keyword

Amniotic membrane; Corneal perforation; Corneal ulcer; Fibrin glue; Moxifloxacin

MeSH Terms

Amnion
Aza Compounds
Corneal Perforation
Corneal Ulcer
Fibrin Tissue Adhesive
Humans
Keratitis
Quinolines
Recurrence
Transplants
Aza Compounds
Fibrin Tissue Adhesive
Quinolines

Figure

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  Figure 1 Preparation of moxifloxacin mixed fibrin glue.

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  Figure 2 (A) On initial examination, subtotal corneal infectious infiltration with hypopyon and impending corneal perforation was shown. (B) Fourteen days after surgery, the corneal infiltration was remarkably decreased in size and partial epithelial healing was obtained. (C) 4 weeks after surgery, complete re-epithelization was observed. (D) 3 months after surgery, infected and perforated cornea was completely healed.

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  Figure 3 (A) On initial examination, corneal perforation with incarcerated iris and epithelial defects with stromal infiltration was shown. (B) Fourteen days after surgery, epithelial defects were partially restored. (C) 1 month after surgery, complete re-epithelization was observed. (D) 3 months after surgery, infected and perforated cornea was completely healed.

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