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Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma through Down-Regulation of COX-2 mRNA and PGEâ‚‚

Pun IH, Chan D, Chan SH, Chung PY, Zhou YY, Law S, Lam AK, Chui CH, Chan AS, Lam KH, Tang JC

PURPOSE: 83b1 is a novel quinoline derivative that has been shown to inhibit cancer growth in human esophageal squamous cell carcinoma (ESCC). This study was conducted to comprehensively evaluate the...
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Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation

Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW

Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after...
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Effects of Interleukin-13 and Montelukast on the Expression of Zonula Occludens-1 in Human Podocytes

Park SJ, Saleem MA, Nam JA, Ha TS, Shin JI

PURPOSE: The aim of this study was to investigate whether pathologic changes in zonula occludens-1 (ZO-1) are induced by interleukin-13 (IL-13) in the experimental minimal-change nephrotic syndrome (MCNS) model and...
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Impact of Statin Treatment on Strut Coverage after Drug-Eluting Stent Implantation

Suh Y, Kim BK, Shin DH, Kim JS, Ko YG, Choi D, Jang Y, Hong MK

PURPOSE: To evaluate the effect of statin treatment on strut coverage after drug-eluting stent (DES) implantation. MATERIALS AND METHODS: In this study, 60 patients were randomly assigned to undergo sirolimus-eluting stent...
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Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells

Hwang WC, Kim MK, Song JH, Choi KY, Min DS

Autophagy is a conserved lysosomal self-digestion process used for the breakdown of long-lived proteins and damaged organelles, and it is associated with a number of pathological processes, including cancer. Phospholipase...
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Effects of intensive versus mild lipid lowering by statins in patients with ischemic congestive heart failure: Korean Pitavastatin Heart Failure (SAPHIRE) study

Lee HY, Cho HJ, Kim HY, Jeon HK, Shin JH, Kang SM, Baek SH

BACKGROUND/AIMS: This study was designed to evaluate the dose-effect relationship of statins in patients with ischemic congestive heart failure (CHF), since the role of statins in CHF remains unclear. METHODS: The...
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Appropriate candidates for statin use in heart failure

Seo HS

No abstract available.
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Epithelial Wound Healing after Cataract Surgery Comparing Two Different Topical Fluoroquinolones

Han KE, Chung WS, Kim TI, Kim S, Kim T, Kim EK

PURPOSE: To compare the epithelial wound healing response of two preservative-free fluoroquinolones, moxifloxacin and levofloxacin, in patients who underwent cataract surgery. MATERIALS AND METHODS: In this prospective, evaluator-masked, randomized clinical trial,...
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Clinical and Microbiologic Characteristics of Clostridium difficile Infection Caused by Binary Toxin Producing Strain in Korea

Kim J, Seo MR, Kang JO, Choi TY, Pai H

BACKGROUND: Binary toxin-producing Clostridium difficile infections (CDI) are known to be more severe and to cause higher case fatality rates than those by binary toxin-negative isolates. There has been few...
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Therapeutic Effect of Combination Treatment of Antihistamine and Montelukast in Allergic Rhinitis

Son HR, Lee KI, Chung YJ, Mo JH

  • KMID: 2297561
  • J Rhinol.
  • 2013 May;20(1):20-25.
BACKGROUND: Montelukast is a type 1 cysteinyl-leukotrienes receptor antagonist that has been widely used in allergic disease. However, the effect of combination of leukotriene receptor antagonist and antihistamine is controversial....
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A Case of Fungal Keratitis Scedosporium apiospermum

Lee S, Lee DW, Lee HS, You IC

PURPOSE: To report a case of fungal keratitis caused by Scedosporium apiospermum. CASE SUMMARY: A 70-year-old man visited our clinic with complaints of redness and decreased visual acuity in his right...
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Ratio of Leukotriene E4 to Exhaled Nitric Oxide and the Therapeutic Response in Children With Exercise-Induced Bronchoconstriction

Baek HS, Cho J, Kim JH, Oh JW, Lee HB

PURPOSE: This study assessed the association between the ratio of leukotriene E4 (LTE4) to fractional exhaled nitric oxide (FENO) in the response of children with exercise-induced bronchoconstriction (EIB) enrolled in...
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Hafnia Alvei Keratitis after Using a Therapeutic Contact Lens in a Patient with Graft-Versus-Host Disease

Park SU, Lee SJ, Lee SC

PURPOSE: To report a case of bacterial keratitis caused by Hafnia alvei after using a contact lens in a patient with graft-versus-host disease. CASE SUMMARY: A 47-year-old male patient presented with...
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Effect of Statins on C-reactive Protein, Lipoprotein(a) and Fibrinogen in Hypercholesterolemic Patients

Cho JH, Kim KJ, Lee WS, Lee KJ, Kim SW, Kim TH, Kim CJ

OBJECTIVE: C-reactive protein (CRP), lipoprotein (a)[Lp(a)], and fibrinogen are associated with systemic inflammatory reactions. Statins have anti-inflammatory effects. However, the effect of statins on these parameters is inconsistent. We evaluated...
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Genetic Classification and Antimicrobial Resistance of Ureaplasma urealyticum Isolated from Urine

Choi M, Park I

Recently, polymerase chain reaction (PCR)-based methods have been used to reclassify Ureaplasma urealyticum into two independent species (spp.), designating U. parvum and U. urealyticum. In the current study, we aim...
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Moxifloxacin Mixed Augmented Amniotic Membrane Transplantation for Perforating Infectious Keratitis

Kim HK

  • KMID: 2338053
  • J Korean Ophthalmol Soc.
  • 2012 Feb;53(2):342-347.
PURPOSE: To report the clinical results of moxifloxacin mixed augmented amniotic membrane transplantation (AMT) in 2 patients with perforating infectious keratitis. CASE SUMMARY: Moxifloxacin mixed augmented amniotic membrane transplantations were performed...
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A Case of Fusarium Keratitis Treated with Moxifloxacin 0.5% Ophthalmic Solution

Lee DC, Lee JW, Chang SD

  • KMID: 2338052
  • J Korean Ophthalmol Soc.
  • 2012 Feb;53(2):338-341.
PURPOSE: To report a case of fusarium keratitis treated with only moxifloxacin 0.5% ophthalmic solution (Vigamox(R), Alcon Laboratories, Inc., Ft Worth, TX, USA). CASE SUMMARY: A 37-year-old healthy male patient experienced...
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Recent Advances of Management for Chronic Myeloid Leukemia

Kim DW

  • KMID: 2264772
  • Korean J Med.
  • 2012 Dec;83(6):718-723.
The clinical outcome for patients with chronic myeloid leukemia (CML) has improved radically in the past 15 years. Imatinib led to high rates of complete cytogenetic responses and improved survival...
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Comparison of the Antibiotic Resistance of Helicobacter pylori Isolated in Jinju Over a 15-year Period

Seo JH, Koo SI, Youn HS, Jun JS, Lim JY, Park CH, Woo HO, Kang HL, Baik SC, Lee WK, Cho MJ, Rhee KH

The aims of this study were to investigate the changing pattern of Helicobacter pylori antibiotic resistance in Jinju over a 15-year period. H. pylori strains were isolated from 170 adults...
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Recent advances in the path toward the cure for chronic myeloid leukemia

Kim DW

Through the phase 3 International Randomized Study of Interferon vs. STI571 (IRIS) trial, imatinib emerged as the standard treatment for chronic myeloid leukemia (CML) and has successfully prolonged the duration...
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