J Korean Ophthalmol Soc.  2008 Oct;49(10):1629-1633.

Clinical Evaluation of Patients with Nonproliferative Diabetic Retinopathy Following Medication of Anthocyanoside: Multicenter Study

• Kim ES
• Yu SY
• Kwon SJ
• Kwon OW
• Kim SY
• Kim TW
• Ahn JK
• Oum BS
• Lew YJ
• Lee JE
• Chung H
• Kwak HW

Abstract

PURPOSE
To prospectively investigate the change of clinical manifestations after 1 year of administration of anthocyanoside (Tagen-F(R)) to patients with NPDR-associated macular edema.
METHODS
One hundred seventy-five eyes in 88 patients were enrolled in this study, at 5 centers, from March, 2005 to October, 2005. Patients took 3 capsules of Vaccinium myrtillus extract (170 mg/capsule, Tagen-F(R), Kukje pharmaceutical) per day. The primary endpoints were corrected visual acuity and contrast sensitivity which were checked at 2 months following the beginning of treatment [East 1]. The secondary endpoints were the number of hard exudates, microaneurysms, leaking points and the changes of foveal thickness. These were examined at the beginning of, 6 months after, and 12 months after treatment.
RESULTS
Corrected visual acuity showed no significant changes during 12 months. Contrast sensitivity improved gradually, especially in 12, 16 cycles per degree [East 2]. There was no statistically significant changes in the numbers of hard exudates, microaneurysms, and leaking points. Foveal thickness measured by OCT was maintained and there was no aggravation of macular edema.
CONCLUSIONS
There was marked improvement of contrast sensitivity in patients with NPDR after 1 year of administration of anthocyanoside (Tagen-F(R)), and it might contribute to the quality of vision and the satisfaction of patients. Visual acuity and macular edema were maintained without aggravation.

Keyword

Anthocyanoside; Diabetic retinopathy; Macular edema

MeSH Terms

Anthocyanins
Capsules
Contrast Sensitivity
Diabetic Retinopathy
Exudates and Transudates
Eye
Humans
Macular Edema
Prospective Studies
Vaccinium myrtillus
Vision, Ocular
Visual Acuity
Anthocyanins
Capsules

Figure

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  Figure 1. The changes of best corrected visual acuity (logMAR).

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  Figure 2. The changes of contrast sensitivity.

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  Figure 3. Compasison of image with different contrast sensitivity; (A) image of high contrast sensitivity (B) image of low contrast sensitivity.

Reference

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