J Korean Ophthalmol Soc.  2006 Nov;47(11):1729-1734.

The Effect of Topical Interferon alpha-2b in the Treatment of Conjunctival Squamous Papilloma

• Kim JY
• Kim YD

Abstract

PURPOSE: To study the effectiveness of Interferon alfa-2b (IFN alpha 2b) for treating squamous papilloma of the conjunctiva.
METHODS
One million units/cc of IFN alpha 2b was applied 4 times a day after identifying squamous papilloma by excisional biopsy. The IFN alpha 2b was used continuously 2 to 6 months after the tumor became undetectable with the unaided eye. The dose was then tapered.
RESULTS
Three of the 4 patients had a history of recurrences (1-4 times). In one patient, the tumor was difficult to remove surgically due to the location of the tumor (around the upper punctum). The tumor disappeared with no complications or recurrences during the follow-up period.
CONCLUSIONS
In patients with conjunctival squamous papilloma with frequent relapses or difficulty in excision, applying IFN alpha 2b as an eye drop appears to be an effective form of therapy and can be used safely without complications.

Keyword

Interferon alfa-2b; Squamous papilloma

MeSH Terms

Biopsy
Conjunctiva
Follow-Up Studies
Humans
Interferons*
Papilloma*
Recurrence
Interferons