J Korean Ophthalmol Soc.  2001 Jan;42(1):208-211.

Amniotic Membrane Transplantation for Late-Onset Filtering Bleb Leaks

• Kim TW
• Kim JH
• Kim DM

Abstract

Successful treatment of late-onset leakage of filtering bleb often requires conjunctival advancement or conjunctival graft with the risk of bleb failure. The authors performed amniotic membrane transplantation in two patients with Seidel-positive late-onset leakage of filtering bleb. In one patient, amniotic membrane transplantation(AMT)was performed twice. In the patient who underwent AMT twice, the bleb became Seidel-negative within 5 weeks of second AMT. However, it became Seidel-positive again within next 7 weeks. In the other patient, the bleb leak was partially resolved within 4 weeks, but became exuberant again within the next 4 weeks. In our experience, AMT had only a limited benefit in treating Seidel-positive bleb leaks. However, its initial success suggests that further studies are necessary to better understand the role of amniotic membrane in bleb leak and to develop a potential therapeutic modality for treating late-onset filtering bleb leak.

Keyword

Amniotic membrane; Late-onset filtering bleb leak

MeSH Terms

Amnion*
Blister*
Humans
Transplants