J Korean Ophthalmol Soc.  1999 Feb;40(2):513-522.

The Comparative Assessment of Filtering Bleb by Timing of subconjunctival Injection of Mitomycin-C in Glaucoma Filtering Surgery

• Lee DW
• Chang MH
• Lee JH

Abstract

In glaucoma filtering surgery, we conducted subconjunctival injection of Mitomycin-C(MMC) 12 hours before and after surgery, and examined histologic findings of the filtering bleb, and condition of the anterior chamber which ensued after the injection. We divided 15 full-grown rabbits into three groups, and for each group, administered subconjunctivally 0.1cc of 0.002%, 0.004%, and 0.008% MMC, respectively. The subconjunctival injection of MMC before surgery was given to the right eye and post-surgical injection to the left, and we examined the results 1, 2, 4, 7, and 14 days after the administration.In conclusion, subconjunctival injection of MMC 12 hours before glaucoma filtering surgery is shown to be more effective than the injection after the surgery.

Keyword

Mitomycin-C; Preoperative-subconjunctival injection; Postoperative-subconjunctival injection; Soaking; Filtering bleb

MeSH Terms

Anterior Chamber
Blister*
Filtering Surgery*
Glaucoma*
Mitomycin*
Rabbits
Mitomycin