J Korean Ophthalmol Soc.  1998 Sep;39(9):2064-2073.

Clinical Evaluation of Domestic Hyal 2000(R) as a Viscoelastic Substance in Phacoemulsification with Posterior Chamver Intraocular Lens

  • 1Department of Ophthalmology, Kangnam St, Mary Hospital, The Cathoic University Medical College, Korea.
  • 2Department of Ophthalmology, College of Medicine, Chungnam National University, Korea.


The efficacy and safety of Hyal 2000(R), the first domestically developed viscoelastic material, was evaluated in patients undergoing phacoemulsification with posterior chamber intraocular lens implantation. We compared the operative efficiency and postoperative reactions such as inflammation and intraocular pressure, corneal endothelial cell density and thickness sixty eyes treated with Hyal 2000 and thirty eyes with the Healon . The corneal endothelial cell loss in the Hyal 2000(R) and Healon(R) groups was 6.7%, 9.2%, 7.8%, 5.7% and 5.5%, 9.0%, 7.6%, 5.2% at the postoperative day 1st, 7th, 30th and 60th respectively. There was no statistical difference between the two groups. The change of corneal thickness in the Hyal 2000(R) and Healon(R) groups was 10.2%, 6.5%, 6.3%, 3.3% and 10.7%, 3.9%, 3.5%, 1.2% at the postoperative 1st, 7st, 30th, 60th day respectively. There were statistically significant differences between the two groups at the postoperative 7th and 30th days respectively(p<0.05). The postoperative inflammation and intraocular pressure showed no difference between two groups. The presented results in this report suggest that Hyal 2000(R) is useful for an effective viscoelastic material in eye surgery.


Corneal endothelial cell; corneal thickness; Viscoelastic; Intracoular pressure; Phacoemulisification

MeSH Terms

Corneal Endothelial Cell Loss
Endothelial Cells
Hyaluronic Acid
Intraocular Pressure
Lens Implantation, Intraocular
Lenses, Intraocular*
Hyaluronic Acid
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