J Korean Ophthalmol Soc.  1996 Dec;37(12):2104-2110.

The Effect of Bromocriptine on the Inhibition of Eyeball Growth at Various Concentration in Myopic Chicken Model

• Min BM
• Lee CH
• Lee YH
• Cha MB
• Hong ST

Abstract

The authors examined the effect and concentration dependency of bromocriptine on the inhibition of axial length elongation in the experimentally induced myopic chicken. Two day-old white Leghorn chicken was monocularly deprived of form vision by lid suture. We measured the axial length of chicken's eye by ultrasonography at 2 day, 2 week, 4 week, and 6 week following repeated ophthalmic dosing beginning at 2 day. The first group was instilled with 0.1 cc of Tris buffer solution, whereas the second, third, and fourth groups were instilled with 0.1cc of 0.01 %, 0.02%, 0.04% bromocriptine solution respectively. All solutions were instilled twice daily for 6 weeks. In the inhibition of axial length elongation, the third group (0.02% bromocriptine) was most effective at 2 week (p<0.05), whereas the second group (0.01% bromocriptine) was most effective at 4 and 6 week (p<0.05). In summary, the axial length elongation of eyeball was effectively retarded by bromocriptine with the best efficacy at 0.02% in short-term dosing while at 0.01% in long-term dosing.

Keyword

Axial length; Bromocriptine; Myopic chicken eyeball

MeSH Terms

Bromocriptine*
Chickens*
Sutures
Tromethamine
Ultrasonography
Bromocriptine
Tromethamine