J Korean Ophthalmol Soc.  1992 Jan;33(1):1-10.

The Clinical Study of the Effective Treatment of Blepharospasm and Hemifacial Spasm with Botulinum toxin A (Oculinum(R))(II)

• Kim JC
• Hong NS
• Kim WS
• Koo BS

Abstract

Two hundred sixty two patients of the essential blepharospasm and hemifacial spasm were treated with Botulinum toxin A (Oculinum(R)). A total of 620 treatments was given injections over a 3-year period. A reduction in spasm intensity was noted in most patients, and the mean response time of the essential blepharospasm and hemifacial spasm were 144.2 days and 172.3 days, respectively, There was no clear relationship between age, sex, toxin dose or preinjected spasm intensity, the amount of spasm reduction, and the mean response time. The mean respone time had no difference from the first through the fourth treatments; but in hemifacial spasm, the mean response time of the second treatment was longer than that of first, third and fourth treatments. The lagophthalmos and superficial punctate keratitis were the most frequent complications. As a result of the injection to avoid the center of the upper and lower eyelids, the frequency of complications could be minimized. There was no clear difference in the beneficial effect and the mcidence of complication (lagophthalmos) between toxin stored in the vaccum and in the non-vaccum state. Patients who were treated with lidocaine mixed toxin had a less effective result than those with saline-mixed toxin.

Keyword

Botulinum toxin A; Blepharospasm; Hemifacial spasm; Lagophthalmos; Superficial punctate keratitis

MeSH Terms

Blepharospasm*
Botulinum Toxins*
Eyelids
Hemifacial Spasm*
Humans
Keratitis
Lidocaine
Reaction Time
Spasm
Botulinum Toxins
Lidocaine