J Korean Ophthalmol Soc.  1990 Jan;31(1):59-68.

Treatment of Blepharospasm and Hemifacial apasm with Botulinum Toxin A(Oculinum(R))(I)

• Koo HN
• Kim JC
• Koo BS

Abstract

Twenty cases of blepharospasm and thirty five cases of hemifacial spasm were treated by injection with Botulinum Toxin A during a fifteen-month period. A total of 74 treatment sessions were given for 7 months follow-up period and the mean dose of 17.81 units per lid and brow was administered according to Scott's method. The mean ages of blepharospasm and hemifacial spasm patients were 59 years and 49 years, respectively. The mean response time of toxin against blepharospasm and hemifacial spasm were 159.9 days and 167.1 days respectively. The maximum effect of toxin appeared in the first 1 month period following injection. The mean preinjection spasm grade was +3.17 in blepharospasm, and +2.41 in hemifacial spasm, and mean postinjection spasm grade was +0.88 in blepharospasm and +0.52 in hemifacial spasm. The mean preinjection muscle strength was +3.15 in blepharospasm, and +3.07 in hemifacial spasm, and mean postinjection muscle strength was +1.12 in blepharospasm, and +1.24 in hemifacial spasm. The complications attributed to toxin injection were lagophthalmos, and epiphora. These ocular complications were localized, mild and transient, and no systemic side effects were noted.

Keyword

Botulinum Toxin A; Eyelid spasm

MeSH Terms

Blepharospasm*
Botulinum Toxins*
Follow-Up Studies
Hemifacial Spasm
Humans
Lacrimal Apparatus Diseases
Muscle Strength
Reaction Time
Spasm
Botulinum Toxins