J Korean Pediatr Soc.  2003 Nov;46(11):1080-1084.

Comparison of Clinical Courses According to the Existence of Patent Ductus Arteriosus in Respiratory Distress Syndrome

• Seong JH
• Lee HJ
• Hong HK
• Bae CW
• Choi YM

Abstract

PURPOSE
To compare perinatal characteristics, clinical courses, and overall morbidity between respiratory distress syndrome(RDS) with patent ductus arteriosus(PDA) and RDS without PDA in neonates.
METHODS
Eighty-three neonates who were diagnosed and treated for RDS in the neonatal intensive care unit(NICU) from Jan. 2000 to Dec. 2002 were included in this study. RDS was complicated with PDA(group A) in 17 patients and not complicated in 66(group B). PDA was diagnosed by echocardiogram in neonates with congestive heart failure symptom, cardiac murmur or chest X-ray findings of cardiomegaly or pulmonary edema. A retrospective study was undertaken of the perinatal charac teristics and overall morbidity in group A and group B.
RESULTS
The birth weight and gestational periods of group A were less compared with group B. There was more perinatal asphyxia in group A. Incidence of overall morbidity such as bronchopul monary dysplasia, intraventricular hemorrhage and death was higher in group A. Intravenous indomethacin was administered in 17 PDA infants.
CONCLUSION
The perinatal characteristics in the two groups showed a significant difference. Incidence of overall morbidity in the two groups showed significant differences, however, there is no simple conclusion to draw because we didn't do multifactorial analyses to rule out other many risk factors affecting morbidity, such as gestational weeks or birth weight.

Keyword

Respiratory distress syndrome; Patent ductus arteriosus; Indomethacin; New-born Infant

MeSH Terms

Asphyxia
Birth Weight
Cardiomegaly
Ductus Arteriosus, Patent*
Heart Failure
Heart Murmurs
Hemorrhage
Humans
Incidence
Indomethacin
Infant
Infant, Newborn
Intensive Care, Neonatal
Pulmonary Edema
Retrospective Studies
Risk Factors
Thorax
Indomethacin