J Korean Pediatr Soc.  2002 Feb;45(2):256-261.

MRI Finding of a Case of Relapsed Acute Mixed Type Leukemia with Bone Marrow Necrosis

• Park JY
• Park E
• Park SB
• Jeon DS
• Lee HJ
• Kim HS
• Kang CM

Abstract

Bone marrow necrosis is a rare complication of a variety of diseases affecting the marrow. The cause and incidence are unknown, and reports of treatment response are rare. We describe a case of relapsed acute mixed type leukemia with bone marrow necrosis. The patient was a 10 year old female diagnosed with acute mixed type leukemia four years ago. She had been on second remission state for 1 year, presented with severe back pain, tenderness in lower extremities, low-grade fever and general weakness. Her level of serum lactic dehydrogenase on admission was increased. Bone marrow aspiration from both posterior iliac crest showed marrow necrosis. Subsequent examination showed the same feature. Hip MRI showed heterogenous low signal intensity in both iliac bone on T-1 weighted image and heterogenous high signal intensity on T-2 wieghted image. Remission induction therapy was started but she expired on 59th hospital day due to the complication of sepsis.

Keyword

Bone marrow necrosis; Leukemia

MeSH Terms

Back Pain
Bone Marrow*
Child
Female
Fever
Hip
Humans
Incidence
Leukemia*
Lower Extremity
Magnetic Resonance Imaging*
Necrosis*
Oxidoreductases
Remission Induction
Sepsis
Oxidoreductases