J Korean Pediatr Soc.
1999 May;42(5):644-649.
Pulmonary Inflammatory Cells in Preterm Infants with Respiratory Distress Syndrome Followed by Surfactant Treatment
- Affiliations
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- 1Department of Pediatrics, Pundang Jesaeng General Hospital.
- 2Department of Clinical Pathology*, Pundang CHA Geneneral Hospital, Sungnam, Korea.
Abstract
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PURPOSE: The effect of surfactant treatment on inflammatory cell populations has not been determined. I evaluated the effect of surfactant treatment on a number and distribution of inflammatory cells in bronchoalveolar lavage fluid(BALF) from the preterm infants who were dependent on mechanical ventilation over the 1st week of life.
METHODS
This study included 8 preterm infants with respiratory distress syndrome(RDS) who received surfactant(Exosurf, 67.5mg/kg Dipalmitoyl phosphatidylcholine(DPPC) with a volume of 5 ml/kg, single dose)on their first day of life and 7 preterm infants of similar severity who did not. BALFs were collected on days 2, 3, 5, and 7 after birth. Cell counts were performed from the obtained BALFs, then they were applied to cytospin and Wright stain, and the differentials were calculated on 200 cells.
RESULTS
Surfactant treatment had no significant effect on the number of BALF white cells on days 2-7. Polymorphonuclear cell numbers were not different in both groups on days 2 7. Macrophage cell numbers were higher overall in surfactant treated babies compared to those in untreated babies on days 2-7(P<0.05).
CONCLUSION
Surfactant treatment appeared to accelerate the appearance of macrophages in BALF.
