J Korean Pediatr Soc.
1997 Jul;40(7):981-990.
Urinary Interleukin-1beta Levels in Children with Urinary Tract Infection
- Affiliations
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- 1Department of Pediatrics, College of Medicine, Ewha Woman's University, Seoul, Korea.
Abstract
- PURPOSE
IL-1beta and TNF-alpha are important mediators of the inflammatory response in serious bacterial infections. The mucosal and systemic IL-1beta and TNF-alpha responses to urinary tract infection are analyzed in children with acute urinary tract infection.
METHODS
We studied the levels of these two cytokines in the urine and sera of 21 children at diagnosis and after treatment with sandwich ELISA method.
RESULTS
The mean urinary IL-1beta level in acute UTI was 3.9pg/ml compared with 1.5pg/ml in febrile group and 1.6pg/ml in the normal control group (P<0.05). TNF-alpha was not elevated in urine in children with UTI or other groups. These results suggest that bacteriuria is accompanied by elevated urinary IL-1beta levels and that this IL-1beta may be locally produced.
CONCLUSION
IL-1beta is elevated in urine of children with urinary tract infection. This may be due to a local inflammatory response in the urinary tract. Variation in local cytokine production with time and the clinical significance of these observations require further study.
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