J Korean Rheum Assoc.
2005 Dec;12(4):320-323.
A Case of Improved Refractory Uveitis in Behcet's Disease after Infliximab Therapy
- Affiliations
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- 1Department of Allergy-Rheumatology, Ajou University School of Medicine, Suwon, Korea. chsuh@ajou.ac.kr
- 2Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea.
Abstract
- Behcet's disease is a multisystemic, chronic relapsing inflammatory disease characterized by vasculitides, mucocutaneous lesions, thrombophlebitis, arthritis. Among them, the ocular involvement is usual (50~70%) and the most serious morbidity is blindness (20~25% of those of affected). Immunosuppressive treatment is currently the main therapy in chronic relapsing uveitis, but many patients experience recurrent sight-threatening uveitis. T lymphocytes play an important role in the pathogenesis of uveitis by releasing cytokines such as tumor necrosis factor (TNF) alpha. There are some reports that the anti-TNFalpha treatment is effective in refractory Behcet's uveitis, but it has not been reported in Korea. We report a case of refractory uveitis in Behcet's disease which is improved after anti-TNFalpha therapy.
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