J Korean Rheum Assoc.  2005 Sep;12(3):240-244.

Ankylosing Spondylitis associated with Plasmacytoma: a Case Report

• Kim YN
• Lee HE
• Lee SH
• Lee YA
• Woo DH
• Hwangbo Y
• Cho KS
• Park YK
• Yang HI

Abstract

Plasmacytomas are tumors composed of plasma cells of variable maturity, which are histologically identical to those seen in multiple myeloma. Ankylosing spondylitis is a chronic inflammatory disease, probably resulting from the interaction of a genetic predisposition involving HLA-B27 with an environmental event such as enteric bacterial infection. Multiple myeloma has been intermittently reported in patients with ankylosing spondylitis. It has been proposed that the protracted stimulation of immunocytes by inflammatory lesions on the mucosal surfaces of the gastrointestinal, respiratory tracts may be implicated in the pathogenesis of multiple myeloma in some patients. We observed a 23 year old male patient with a history of plasmacytoma who subsequently developed ankylosing spondylitis. He was diagnosed as plasmacytoma 4 years ago and took a radiation therapy. There was no previous report of ankylosing spondylitis following plasmacytoma. The relationship between two diseases is uncertain until now and further study should be needed.

Keyword

Multiple myeloma; Plasmacytoma; Ankylosing spondylitis

MeSH Terms

Bacterial Infections
Genetic Predisposition to Disease
HLA-B27 Antigen
Humans
Male
Multiple Myeloma
Plasma Cells
Plasmacytoma*
Respiratory System
Spondylitis, Ankylosing*
Young Adult
HLA-B27 Antigen