J Korean Soc Biol Psychiatry.  1999 Jul;6(1):12-20.

A Study on Developing Computer Models of Neuropsychiatric Diseases

• Koh IS
• Park JW

Abstract

In order to understand the pathogenesis and progression of some synaptic loss related neuropsychiatric diseases. We attempted to develop a computer model in this study. We made a simple autoassociative memory network remembering numbers, transformed it into a disease model by pruning synapses, and measured its memory performance as a function of synaptic deletion. Decline in performance was measured as amount of synaptic loss increases and its mode of declines is sudden or gradual according to the mode of synaptic pruning. The developed computer model demonstrated how synaptic loss could cause memory impairment through a series of computer simulations, and suggested a new way of research in neuropsychiatry.

MeSH Terms

Computer Simulation*
Dementia
Memory
Neuropsychiatry
Schizophrenia
Synapses