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Opioids and Antidepressants for Pain Control in Musculoskeletal Disease

Park SJ, Kim WS, Jang T

The progression of aging and the increase in musculoskeletal diseases have led to an increase in invasive treatment methods, including various surgical methods, but conservative treatment should be attempted before...
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Can we delineate preoperatively the right and ventral margins of caudate lobe of the liver?

Shen XY, Wang HJ, Kim BW, Hong SY, Kim MN, Hu XG

PURPOSE: Complete removal of the caudate lobe, which is sometimes necessary, is accomplished via isolated caudate lobectomy or hepatectomy that includes the caudate lobe. It is impossible, however, to confirm...
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Layer-specific cholinergic modulation of synaptic transmission in layer 2/3 pyramidal neurons of rat visual cortex

Cho KH, Lee SY, Joo K, Rhie DJ

It is known that top-down associative inputs terminate on distal apical dendrites in layer 1 while bottom-up sensory inputs terminate on perisomatic dendrites of layer 2/3 pyramidal neurons (L2/3 PyNs)...
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Activated Leukocyte Cell Adhesion Molecule Modulates Th2 Immune Response in Atopic Dermatitis

Oh MS, Hong JY, Kim MN, Kwak EJ, Kim SY, Kim EG, Lee KE, Kim YS, Jee HM, Kim SH, Sol IS, Park CO, Kim KW, Sohn MH

PURPOSE: Activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily, is highly expressed on dendritic cells. ALCAM and its receptor CD6 are co-stimulatory molecules in the immunological...
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Vesicular Glutamate Transporter 1 (VGLUT1)- and VGLUT2-containing Terminals on the Rat Jaw-closing γ-Motoneurons

Park SK, Hong JH, Jung JK, Ko HG, Bae YC

Currently, compared to jaw-closing (JC) α-motoneurons, the information on the distribution and morphology of glutamatergic synapses on the jaw-closing (JC) γ-motoneurons, which may help elucidate the mechanism of isometric contraction...
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Publication patterns in Restorative Dentistry and Endodontics

Chockattu , Deepak BS

OBJECTIVES: Restorative Dentistry and Endodontics (Restor Dent Endod; RDE) is an English-language journal published by the Korean Academy of Conservative Dentistry, and it has been online since 2012 with quarterly...
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Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala

Lee S, Kim JH

The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors: formation and extinction of fear memory and appetitive instrumental learning....
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Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease

Tang J, Oliveros A, Jang MH

Synapses are sites of high energy demand which are dependent on high levels of mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are key for maintenance of functional neurotransmission and...
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Restorative Mechanism of Neural Progenitor Cells Overexpressing Arginine Decarboxylase Genes Following Ischemic Injury

Kim JY, Kim JY, Kim JH, Jung H, Lee WT, Lee JE

Cell replacement therapy using neural progenitor cells (NPCs) following ischemic stroke is a promising potential therapeutic strategy, but lacks efficacy for human central nervous system (CNS) therapeutics. In a previous...
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A Comparison of Manual and Three-Dimensional Modalities in Predicting Nellix Polymer Volume

Elbasty A, Mughal N, Delbridge

PURPOSE: Achieving an effective seal with the Nellix endovascular aneurysm system is dependent on filling the stent bags with an appropriate volume of polymer. Calculating this volume preoperatively is essential...
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Phagocytic Roles of Glial Cells in Healthy and Diseased Brains

Jung YJ, Chung WS

Glial cells are receiving much attention since they have been recognized as important regulators of many aspects of brain function and disease. Recent evidence has revealed that two different glial...
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Cortical Axonal Secretion of BDNF in the Striatum Is Disrupted in the Mutant-huntingtin Knock-in Mouse Model of Huntington's Disease

Park H

Deficient BDNF signaling is known to be involved in neurodegenerative diseases such as Huntington's disease (HD). Mutant huntingtin (mhtt)-mediated disruption of either BDNF transcription or transport is thought to be...
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Intravenous Anesthetic, Propofol Affects Synaptic Responses in Cerebellar Purkinje Cells

Lee KY, Jang Y, Lee MH, Kim YI, Jung SC, Han SY, Kim SH, Park HS, Kim DK

OBJECTIVE: Propofol is an intravenously administered anesthetic that enhances γ-aminobutyric acid-mediated inhibition in the central nerve system. Other mechanisms may also be involved in general anesthesia. Propofol has been implicated...
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Expression of µ-Opioid Receptor in CA1 Hippocampal Astrocytes

Nam MH, Han KS, Lee J, Bae JY, An H, Park S, Oh SJ, Kim E, Hwang E, Bae YC, Lee CJ

µ-opioid receptor (MOR) is a class of opioid receptors with a high affinity for enkephalins and beta-endorphin. In hippocampus, activation of MOR is known to enhance the neuronal excitability of...
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Astrocytes, Microglia, and Parkinson's Disease

Joe EH, Choi DJ, An J, Eun JH, Jou I, Park S

Astrocytes and microglia support well-being and well-function of the brain through diverse functions in both intact and injured brain. For example, astrocytes maintain homeostasis of microenvironment of the brain through...
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A De Novo RAPGEF2 Variant Identified in a Sporadic Amyotrophic Lateral Sclerosis Patient Impairs Microtubule Stability and Axonal Mitochondria Distribution

Heo K, Lim SM, Nahm M, Kim YE, Oh KW, Park HT, Ki CS, Kim SH, Lee S

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is frequently linked to microtubule abnormalities and mitochondrial trafficking defects. Whole exome sequencing (WES) of patient-parent trios has proven to...
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Dual mechanisms for the regulation of brain-derived neurotrophic factor by valproic acid in neural progenitor cells

Ko HM, Jin Y, Park HH, Lee JH, Jung SH, Choi SY, Lee SH, Shin CY

Autism spectrum disorders (ASDs) are neurodevelopmental disorders that share behavioral features, the results of numerous studies have suggested that the underlying causes of ASDs are multifactorial. Behavioral and/or neurobiological analyses...
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Presynaptic Dysfunction by Familial Factors in Parkinson Disease

Lee W, Koh S, Hwang S, Kim SH

Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer disease. The loss of specific brain area, the substantia nigra pars compacta is known as a major etiology,...
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Differential Expression of Ca²⁺-buffering Protein Calretinin in Cochlear Afferent Fibers: A Possible Link to Vulnerability to Traumatic Noise

Sharma K, Seo YW, Yi E

The synaptic contacts of cochlear afferent fibers (CAFs) with inner hair cells (IHCs) are spatially segregated according to their firing properties. CAFs also exhibit spatially segregated vulnerabilities to noise. The...
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Publication Delay of Korean Medical Journals

Lee Y, Kim K, Lee Y

Publication lag is a determinant to journal efficiency that was not yet studied concerning Korean medical journals. To measure publication lag, we investigated the publication timestamps of 4,762 articles published...
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