J Korean Epilepsy Soc.
2005 Jun;9(1):21-26.
Encoding and Retrieval of Words and Scenes Assessed by Functional MRI in Normal Right-Handed Volunteers
- Affiliations
-
- 1Department of Neurology, Korea University, Guro Hospital, Seoul, Korea.
- 2Department of Psychology, University of Korea, Korea.
- 3Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- 4Diagnostic Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Abstract
- PURPOSE
To find the activation patterns of frontal and medial temporal lobe during memory tasks (encoding and retrieval) with novel stimuli (words, scenes) in normal right-handed volunteers. Another aim is to examine which memory paradigms and processes are effective to activate medial temporal lobe. METHODS: We included 10 right-handed normal volunteers. Stimuli consisted of encoding and retrieval of novel word (15 items)/novel scenes (15 items). During scanning, each stimulus was presented for 2000 ms. Imaging was performed on 1.5 GE scanner. Group analysis was performed in volunteers with SPM 2 (uncorrected p<0.005, voxels>10). RESULTS: Scenes encoding and retrieval activated both medial temporal lobes, more on the right side. Word encoding activated predominantly dominant frontal lobe, but failed to activate the medial temporal lobes. The word stimuli activated more the frontal lobe than the picture stimuli. Retrieval process activated more the medial temporal lobe than encoding process. CONCLUSION: Our results showed that the scenes encoding/retrieval and word retrieval are useful to activate the medial temporal lobe and word encoding is useful for activating dominant frontal lobe. Further studies will be necessary in patient groups with unilateral temporal lobe lesion to document the usefulness of this study.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Neural Mechanism of Implicit and Explicit Memory Retrieval: Functional MR Imaging
- Functional Mapping of the Neural Basis for the Encoding and Retrieval of Human Episodic Memory Using H215O PET
- Determination of Hemispheric Language Dominance Using Functional MRI: Comparison of Visual and Auditory Stimuli
- Functional MRI Study for Phonological and Semantic Language Processing in Strongly Right-Handed Korean Twenty Year Olds
- Localization of motor speech area by functional MRI during word generation
