J Korean Diabetes Assoc.  2006 Jan;30(1):1-9.

Physical Activity and Type 2 Diabetes Mellitus

• Min KW
• Park SW

Abstract

No abstract available.

MeSH Terms

Diabetes Mellitus, Type 2*
Motor Activity*

Figure

• 

  Fig. 1 Hormonal control and the interaction between the brain, liver, muscle, and fat cell in control of glucose homeostasis.

• 

  Fig. 2 Exercise an insulin signaling in skeletal muscle. Exercise and insulin use distinct signaling mechanism leading to GLUT4 translocation.

• 

  Fig. 3 Effects of endurance exercise training on insulin sensitivity and lipoprotein-lipid metabolism.

Reference

1. Sushruta SCS. Vaidya Jadavaji Trikamji Acharia 13th Rev. 1938. 3rd Ed. Bombay: Nirnyar Sagar Press;(original book published in 500 BC).

2. American Diabetes Association. Exercise and NIDDM (Technical Review). Diabetes Care. 1990. 13:785–789.

3. American Diabetes Association. Diabetes mellitus and exercise(Position Statement). Diabetes Care. 1990. 13:804–805.

4. Schneider SH, Morgado A. Effects of fitness and physical training on carbohydrate metabolism and associated cardiovascular risk factors in patients with diabetes. Diabetes Rev. 1995. 3:378–407.

5. Knowler WC, Narayan KMV, Hanson RL, et al. Perspective in Diabetes. Preventing Non-insulin-dependent Diabetes. Diabetes. 1995. 44:483–488.

7. Wasserman D. Control of glucose fluxes duing exercise in the postabsorptive state. Annu Rev Physiol. 1995. 191:191–218.

8. Wasserman DH, Lickley HLA, Vranic M. Ineractions between gluagon and other counterregulatory hormanes during normoglycemic and hypoglycecie exercise. J Clin Invest. 1984. 74:1404.

9. Kjaer M, Engfred K, Fernandez A, et al. Regulation of hepatic GP during exercise in humans: Role of symmpathoadrenergic activity. Am J Phsiol. 1993. 265:E275.

10. Bjorntorp P. Effects of exercise on plasma insulin. Int J Med. 1981. 2:125–129.

11. Bjorntorp P, Dejounge K, Spostrom L, Sullivan L. The effects of physical trainning on insulin production in obesity. Metabolism. 1980. 19:631–638.

12. Rogental M, Haskell WL, Solomon R, Widstrom A, Reaven GM. Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilization in normal humans. Diabetes. 1983. 32:408–411.

13. Devlin JT, Hirshman M, Horton ED, Horton ES. Enhanced peripheral and splanchnic insulin sensitivity in NIDDM men after a sing bout of exercise. Diabetes. 1987. 36:434–439.

14. Horton ES, Davlin JT. Alberti KGMM, Mazze RS, editors. Exercise and non-insulin dependent diabetes mellitus. current Trends in non-insulin dependent diabetes mellitus. 1989. Amsterdam: Exerpta;271–284.

15. Ivy JL, Holloszy JO. Persistent increase in glucose in glucose up take by rat skeletal muscle following exercise. Am J Physiol. 1981. 241:C200–C203.

16. Bogardus C, Ravussin E, Robbins DC, Wolfe DC, Horton ES, Sims EAH. Effects of physical training and diet therapy on carbohydrate matabolism in patients with glucose intolerance and non-insulin dependent diabetes mellitus. Diabetes. 1984. 33:311–318.

17. King AC, Haskell WI, Taylor CB, Kraemer HC, Debusk RF. Home based exercise training healthy older men and woman. JAMA. 1991. 266:1535–1542.

18. Koivisto VA, soman V, Conrad P, Hendler R, Nadel E, Felig P. Insulin binding to monocytes in trained athletes: changes in the resting state and after exercise. J Clin invest. 1979. 64:1011–1015.

19. Dohm GL, Sinha MK, Caro JF. Insulin receptor binding and protain kinase activity in muscles of tained rats. Am J Physiol. 1987. 252:E170–E175.

20. Burnstein R, polychronakos C, Toews CJ, MacDougall JD, Guyda HJ, posner BI. Acute reversal of enhanced insulin action in trained athletes. Diabetes. 1987. 36:434–439.

21. King PA, Horton ED, Hirshman MF, Horton ES. Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation. J Clin Invest. 1992. 90:1568–1575.

22. O'Dea K. Marked imporvement in carbohydrate and lipid metabolism in diabetes Australian Aborigines after temporary reversion to a traditional lifestyle. Diabetes. 1984. 33:596–603.

23. Rogers MA, Yamamoto C, King DS, hagberg JM, Ehasani AA, Holloszy JO. Improvement in glucose tolerance after 1 week of exercise in patients with mild MIDDM. Diabetes Care. 1988. 11:613–618.

24. Wing RR, Epstein LH, Paternostro-Bayles M, Kriska A, Nowalk MP, Gooding W. Exercise in a behavioral weight control programme for obese patients with type II diabetes. Diabetologia. 1988. 31:902–909.

25. Vanninen E, Uusitupa M, Siitonen O, Laitinen J, Lansimies E. Habitual physical activity, aerobic capacity and metabolic control in patients with newly diagnosed type II diabetes mellitus: effect of a one year diet and exercise intervention. Diabetologia. 1992. 35:340–346.

26. Lehmann R, Vokac A, Niedermann K, Agosti K, Spinas GA. Loss of abdominal fat and improvement of the cardivascular risk profile by regular moderate exercise training in patients with NIDDM. Diabetologia. 1995. 38:1313–1319.

29. Eriksson KF, Lindgarde F. Prevention of type 2 (non-insulin dependent) diabetes mellitus by diet and physical exercise: the six year Malmo feasibility study. Diabetologia. 1991. 34:891–898.

30. Schneider SH, Amorosa LF, Khachadurian AK, Ruderman NB. Studies on the mechanism of imporved glucose control during regular exercise in type 2 (non-insulin dependent) diabetes mellitus. Diabetologia. 1984. 26:355–360.

31. Vu Tran, Weltman A, Glazes G, Mood D. The effects of exercise on plasma lipids and lipoproteins: a meta-analysis of studies. Med Sci Sports Exerc. 1983. 15:393–402.

32. Laws A, Reaven GM. Evidence for an independent relationship between insulin resistance and fasting plasma HDL-cholesterol, triglyceride and insulin concentration. J Intern Med. 1992. 232:25–30.

33. Ferrannini E, Buzzigoli G, Bonadonna R, et al. Insuling resistance in essential hypertension. N Engl J Med. 1987. 317:350–357.

34. DeFronzo RA. The effect of insulin on renal solium metabolism. Diabetologia. 1981. 21:165–171.

35. Schneider SH, Kim HC, Khachandurian AK, Ruderman NB. Impaired fibrinolytic response to exercise in type 2 diabetes: effects of exercise and physical training. Metabolism. 1988. 37:924–929.

36. Gris JC, Schved JF, Aguilar-Martinez P, Amaud A, Sanchez N. Impact of physical training on plasminogen activator inhibitor activity in sedentary men. Fibrinolysis. 1988. 4:Suppl. 2. 97–98.

37. Juhan Vague I, Alessi MC, Vague P. Increased plasminogen activator inhibitor 1 levels A possible link between insulin resistance and ather-othrombosis. Diabetplogia. 1991. 34:457–462.

38. Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its comolications: Estimates and projections to the year 2010. Diabetic Med. 1997. 12:Suppl. 5. S7–S15.

39. Greener M. Counting the Cost of diabetes. Cost and options in diabetes. 1997. 10:4–5.

40. Tuommilehto J, Knowler WC, Zimmet P. Primary Prevention of Non-insulin-dependent Diabetes. Diabetes Metab Rav. 1992. 8:339–353.

41. Bennett PH. Impaired Glucose Tolerance-a target for intervention? Arteriosclerosis. 1985. 5:315–317.

42. Nagi DK, Knowler WC, Charles MA, et al. Early and late insulin response as predictors of NIDDM in indians with impaired glucose tolerance. Diabetogis. 1995. 38:187–192.

43. Saad MF, Knowler WC, Pettitt DJ, Nelson RG, Mott DG, Bennett PH. The natural history of glucose intolerance in the Pima indians. N Engl J Med. 1988. 319:1500–1506.

44. Kadowaki T, Miyaki Y, Hagora R, et al. Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diebetologia. 1984. 26:44–49.

45. King H, Zimmet P, Raper LR, Balkau B. The natural history of impaired glucose tolerance in the micronesian population of Nauru: a 6 year follow-up study. Diabetologia. 1984. 26:39–43.

46. King H, Kriska AM. Prevention of type 2 diabetes by physical training. Diabetes Care. 1992. 15:1794–1799.

47. Narayan KMV, Hoskin M, Kozak D, et al. Radomised clinical trial of life style interventions in Pima Indians a pilot study. Diabetic Med. 1998. 15:66–72.

48. Mason JE, Rimm RB, stamfer MJ, et al. A prospective study of exercise and incidence of diabetes among US mal physicians. JAMA. 1992. 268:63–67.

49. Helmrich SP, Ragland DR, Leung RW, Paffenbager RS. Physical activity and reduced occurrence of non-insulin-depedent diabetes mellitus. N Engl J Med. 1991. 325:147–152.

50. Mason JE, Rimm RB, stamfer MJ, et al. Physical activity and incidence of non-insulin-dependent diabetes in woman. Lancet. 1991. 338:774–778.

51. Pan X, Li G, Hu Y, et al. Effects of diet and exercise in preventing NIDDM in people with Impaired Glucose Tolerance. Diabetes Care. 1992. 20:537–544.

52. Tuomilehto J, Lindstrom J, Erksson JG, Valle TT, Hamalainen H, IlanneParikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M. Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001. 344:1343–1350.

53. Knowler WC, Marrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Diabetes precention program Research Group. Reductio in the incidence of Type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002. 346:393–403.