J Korean Soc Endocrinol.
2001 Feb;16(1):115-122.
2 Cases of Ectopic ACTH Syndrome due to Thymic Neuroendocrine Carcinoma Associated with Different Clinical Manifestations
- Affiliations
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- 1Division of Endocrinology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University of Medical School, Seoul, Korea.
- 2Department of Pathology, Samsung Medical Center, Sungkyunkwan University of Medical School, Seoul, Korea.
- 3Departmeut of Internal Medicine, College of Medicine, Gyeongsang National University, Chinju, Korea.
Abstract
- Primary neuroendocrine carcinoma of the thymus (formerly known as thymic carcinoids) are unusual tumors that account for 5% of all anterior mediastinal neoplasms. Thymic neuroendocrine carcinomas exhibit a much more aggressive behavior than those originating from other foregut locations and are associated with the ectopic ACTH syndrome in 38% of cases. Patients having a thymic neuroendocrine carcinoma usually present with symptoms such as chest tightness, dyspnea, a palpable neck mass and sometimes a weight gain. We report on 2 patients with thymic neuroendocrine carcinoma who showed different clinical manifestations each other. One presented with a typical. Cushingoid appearance and the other had symptoms of fatigue and weight loss which is a common symptom of malignant tumors.
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