J Korean Child Neurol Soc.  2005 Nov;13(2):195-201.

Genetic Propensity to Neuroinflammatory CNS Diseases in Korean Children: Molecular Typing of HLA Class II

• Park WS
• Lee JH
• Jung HD
• Oh HH
• Kwon SH

Abstract

PURPOSE
The study was aimed to investigate immunogenetic peculiarities of neuroinflammatory CNS diseases in Korean children.
METHODS
A total of 16 children with neuroinflammatory CNS diseases(9 males and 7 females; mean age 7.5+/-4.2 years) were consecutively recruited. Genomic typings were performed on their HLA DRB/HLA DQB genes using PCR-SSOP/SSP techniques with Gel immunoelectrophoresis.
RESULTS
The frequencies of HLA-DRB1*14(38%), HLA-DRB1*15(25%), HLA-DRB3* 02(50%), HLA-DQB1*05(56%) and DQB1*06(44%) were significantly increased compared with a control group. The frequencies of HLA-DRB1*15(50%) and HLA-DQB1*06(63%) were significantly increased in children with ADEM and HLA-DRB3*0202(100%), HLA- DRB1*1302(67%), HLA-DRB3*0301(67%), and HLA-DQB1*0301(67%) in children with multiple sclerosis. HLA-DRB1*1401, HLA-DRB3*0202, and HLA-DQB1*0502 were found in children with acute necrotizing encephalopathy.
CONCLUSION
HLA-DRB1*14, HLA-DRB1*15, HLA-DRB3*02, HLA-DQB1*05 and DQB1*06 may be associated with the susceptibility to neuroinflammatory CNS diseases in Korean children. The frequencies of HLA-DRB1*1501, HLA-DRB5*0101, HLA-DRB3* 0301, and HLA-DQB1*0602 in Korean children with multiple sclerosis were not as high as those in western children. However, HLA-DRB3*0202 was seen in all the children with multiple sclerosis. Our data may provide further evidence that the immunogenetic backgrounds of neuroinflammatory CNS diseases in Korean children are distinctly different from those in Westerns. However, further studies are needed.

Keyword

Neuroinflammatory diseases; HLA-DRB; HLA-DQB; Acute disseminated encephalomyelitis; Multiple sclerosis; Acute necrotizing encephalopathy

MeSH Terms

Central Nervous System Diseases*
Child*
Encephalomyelitis, Acute Disseminated
Female
Humans
Immunoelectrophoresis
Immunogenetics
Male
Molecular Typing*
Multiple Sclerosis