Yeungnam Univ J Med.  2016 Jun;33(1):40-43. 10.12701/yujm.2016.33.1.40.

Rapidly resolved IgG4-related retroperitoneal fibrosis after steroid pulse therapy

Affiliations
  • 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. skpark@amc.seoul.kr
  • 2Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Abstract

Retroperitoneal fibrosis (RF) is a disorder characterized by the presence of a retroperitoneal mass and concurrent systemic inflammation. Some cases of RF are recognized as belonging to the spectrum of immunoglobulin G4-related disease (IgG4-RD). Glucocorticoids are highly effective for treatment of retroperitoneal fibrosis, although the optimal dose and duration of therapy have not been established. An initial dose of prednisone (40-60 mg) daily is usually administered with a tapering scheme. We report on a 55-year-old man diagnosed with IgG4-related RF and successfully treated with a 3-day course of daily 250 mg (4 mg/kg) intravenous methylprednisolone, which resulted in the prompt resolution of urinary obstruction and systemic symptoms.

Keyword

Glucocorticoids; IgG4-related disease; Retroperitoneal fibrosis; Steroid pulse therapy

MeSH Terms

Glucocorticoids
Humans
Immunoglobulins
Inflammation
Methylprednisolone
Middle Aged
Prednisone
Retroperitoneal Fibrosis*
Glucocorticoids
Immunoglobulins
Methylprednisolone
Prednisone
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