Infect Chemother.  2016 Jun;48(2):127-131. 10.3947/ic.2016.48.2.127.

Recurrent Kikuchi's Disease Treated by Hydroxychloroquine

  • 1Department of Infectious Disease, Keimyung University School of Medicine, Daegu, Korea.
  • 2Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.


Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disease, with a specific histopathology. It can be diagnosed clinically, and specific symptoms include fever and cervical lymphadenopathy. The histological finding of KFD in cervical lymph nodes includes necrotizing lymphadenitis. KFD needs conservative treatments. If KFD persists for a long period, steroids or nonsteroidal antiinflammatory drugs can be used to control symptoms. Previous studies have reported the treatment of KFD with hydroxychloroquine (HC) in patients unresponsive to steroids. Herein, we report a case of a 25-year-old female patient diagnosed with KFD unresponsive to steroids, and was successfully treated with HC.


Kikuchi-Fujimoto disease; Lymphadenitis; Hydroxychloroquine

MeSH Terms

Histiocytic Necrotizing Lymphadenitis*
Lymph Nodes
Lymphatic Diseases


  • Figure 1 Multiple enlarged or borderline sized LNs in both level II, III, IV, Va, and Vb.Perinodal infiltration is noted around the enlarged lymph nodes(arrows).

  • Figure 2 The gross specimen consists of a piece of pale tan soft tissue, 1.5 × 0.8 × 0.7 cm.

  • Figure 3 The excisional biopsies of cervical lymph nodes, show (A) aggregates of histiocytes (astra), nonphagocytic and phagocytic, with crescentic nuclei (H&E stains, ×100) and (B) similar findings consisting of many histiocytes with crescent-shaped nuclei (arrowheads) in necrotic background (H&E stains, ×400).


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