Korean J Pain.  2016 Jul;29(3):172-178. 10.3344/kjp.2016.29.3.172.

Serum Vitamin D Status in Iranian Fibromyalgia Patients: according to the Symptom Severity and Illness Invalidation

• Maafi AA
• Ghavidel-Parsa B
• Haghdoost
• Aarabi Y
• Hajiabbasi A
• Shenavar Masooleh I
• Zayeni H
• Ghalebaghi B
• Hassankhani A
• Bidari A

• KMID: 2327638
• DOI: http://doi.org/10.3344/kjp.2016.29.3.172

Abstract

BACKGROUND
This study was designed to assess serum vitamin D status (25-OHD) in the fibromyalgia (FM) patients and to compare it with a healthy control group. It also aimed to investigate the correlation of serum vitamin D level with FM symptom severity and invalidation experiences.
METHODS
A total of 74 consecutive patients with FM and 68 healthy control participants were enrolled. The eligible FM patients completed the Illness Invalidation Inventory (3*I), the Revised Fibromyalgia Impact Questionnaire (FIQR) and a short-form health survey (SF-12). Venous blood samples were drawn from all participants to evaluate serum 25-OHD levels. Mann-Whitney tests and multiple logistic regression analyses were performed and Spearman's correlations were calculated.
RESULTS
88.4% of FM patients had low levels of serum 25-OHD. FM patients had significantly higher level of serum 25-OHD than the control group (17.24 ± 13.50 and 9.91 ± 6.47 respectively, P = 0.0001). There were no significant correlations between serum 25-OHD levels and the clinical measures of disease impact, invalidation dimensions, and health status. Multiple logistic regression analyses revealed that an increased discounting of the disease by the patient's spouse was associated with a 4-fold increased risk for vitamin D deficiency (OR = 4.36; 95% CI, 0.95-19.87, P = 0.05).
CONCLUSIONS
This study showed that although high rates of vitamin D insufficiency or deficiency were seen among FM patients and healthy non-FM participants, but it seems there was no intrinsic association between FM and vitamin D deficiency. Addressing of invalidation experience especially by the patient's spouse is important in management of FM.

Keyword

Chronic pain syndrome; Fibromyalgia; Invalidation; Iran; Surveys and Questionnaires; Vitamin D

MeSH Terms

Fibromyalgia*
Health Surveys
Humans
Iran
Logistic Models
Spouses
Surveys and Questionnaires
Vitamin D Deficiency
Vitamin D*
Vitamins*
Vitamin D
Vitamins

Figure

• 

  Fig. 1 The shape of distribution and variability of serum 25-OHD and Ca levels in fibromyalgia patients and sex matched healthy controls.

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