J Rheum Dis.  2016 Jun;23(3):193-197. 10.4078/jrd.2016.23.3.193.

Successful Treatment of Newly Developed, Intractable Digital Ulcers and Gangrene with Bosentan in Systemic Sclerosis

• Tag HS
• Jun SM
• Lee SG
• Park EK
• Koo DW
• Kim GT

• KMID: 2326736
• DOI: http://doi.org/10.4078/jrd.2016.23.3.193

Abstract

In systemic sclerosis, digital ulcers and gangrene are somewhat common clinical characteristics of obliterative vasculopathy. These manifestations increase morbidities, such as pain, infections, and acroosteolysis. However, patient responses to the appropriate treatments are often inadequate. We treated a patient with systemic sclerosis who had a refractory digital ulcer and gangrene with bosentan, an endothelin receptor antagonist, and observed improvement. Here we systematically review this case.

Keyword

Bosentan; Systemic scleroderma; Gangrene

MeSH Terms

Acro-Osteolysis
Gangrene*
Humans
Receptors, Endothelin
Scleroderma, Systemic*
Ulcer*
Receptors, Endothelin

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