J Neurogastroenterol Motil.
2011 Jan;17(1):67-72.
Validation of New Symptom-Based Fibromyalgia Criteria for Irritable Bowel Syndrome Co-morbidity Studies
- Affiliations
-
- 1Department of Gastroenterology, Soroka Medical Center, Beer-Sheva, Israel. amy@bgu.ac.kr
- 2Department of Medicine H, Soroka Medical Center, Beer-Sheva, Israel.
- 3Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
- 4Sial Research Center for Family Medicine and Primary Care, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
- 5Department of Gastroenterology and Liver Diseases, Tel-Aviv Medical Center, Tel-Aviv, Israel.
- 6Faculty of Management, Tel-Aviv University, Tel-Aviv, Israel.
- 7Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Abstract
- BACKGROUND/AIMS
There is significant co-morbidity between irritable bowel syndrome (IBS) and fibromyalgia syndrome (FMS). However, FMS is diagnosed by physical examination, which limits the conduct of co-morbidity studies in a large population-based study. The purpose of this study was to determine the diagnostic validity of a new symptom-based criteria in patients with FMS and/or IBS using the American College of Rheumatology (ACR) criteria as a gold standard.
METHODS
The study participants consisted of women with FMS (n = 30), IBS (n = 27) and controls (n = 28). A new symptom-based diagnostic criteria for FMS comprised a regional pain scale and a visual analogue scale for fatigue. All subjects underwent a physical examination for FMS (ACR criteria) and structured questionnaires of regional pain scale and visual analogue scale for fatigue. A fibromyalgia intensity score was calculated and thresholds of tenderness were determined by a dolorimeter.
RESULTS
The number of participants diagnosed with FMS in the entire study population (n = 85) was 31 by the new criteria. Compared to the ACR, the sensitivity of the new criteria was 82.9%, specificity 96.0%, positive predictive value 93.5% and negative predictive value 88.9%. In addition, new criteria were useful for the diagnosis of FMS among the subjects with IBS. A fibromyalgia intensity score was significantly correlated with the threshold of tenderness (r = -0.62, P < 0.001).
CONCLUSIONS
The new symptom-based diagnostic criteria for the diagnosis of FMS can be used in large-scale clinical and epidemiological co-morbidity studies, in which physical examination is unfeasible. Gastroenterologists investigating the effects of co-morbid FMS in IBS patients can use these new ciriteria with confidence.
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