J Neurogastroenterol Motil.  2013 Jan;19(1):61-69.

Comparison of Gastroesophageal Reflux Disease Symptoms and Proton Pump Inhibitor Response Using Gastroesophageal Reflux Disease Impact Scale Questionnaire

• Jo SY
• Kim N
• Lim JH
• Shin CM
• Park YS
• Lee DH
• Jung HC

Abstract

BACKGROUND/AIMS
To compare gastroesophageal reflux disease (GERD) symptoms and response to proton pump inhibitor (PPI) in patients with erosive esophagitis (EE), non-erosive reflux disease (NERD) or functional heartburn (FH) using GERD impact scale (GIS) questionnaire.
METHODS
Total 126 patients with GERD symptoms were diagnosed as EE (n = 62), NERD (n = 34) and FH (n = 30) by endoscopy, 24-hour esophageal pH testing and Bernstein test, prospectively. Analysis of risk factors and GIS questionnaire for GERD symptoms and quality of life were performed before and 8 weeks after PPI treatment.
RESULTS
EE group had a higher proportion of men, frequent alcohol consumption, smoking, hiatal hernia, body mass index > or = 25 kg/m2 and triglyceride levels (> or = 150 mg/dL) than the other groups (all P < 0.05). On the other hand, both psychiatric treatment and psychopharmacotherapy were more frequent in patients with FH than in those with EE and NERD (both P < 0.05). Among GERD symptoms, chest pain was more frequent in FH group than in EE and NERD groups (P < 0.05). Eating problems and limitation of productive daily activities occurred frequently in FH group and NERD group, respectively. GIS after 8 week PPI treatment showed improvement in all of the GERD symptoms in EE (all P < 0.05) and in acid regurgitation, epigastric pain and hoarseness in NERD group (all P < 0.05). In terms of quality of life, PPI treatment improved sleep disturbance in EE (P = 0.031) and limitation of productive activity in the NERD group (P = 0.001).
CONCLUSIONS
GIS questionnaire showed that different characteristics and symptoms improved after PPI therapy among patients with EE, NERD and FH, demonstrating the usefulness of the GIS questionnaire.

Keyword

Functional heartburn; Gastroesophageal reflux; Proton pump inhibitors; Quality of life; Questionnaires

MeSH Terms

Alcohol Drinking
Body Mass Index
Chest Pain
Eating
Endoscopy
Esophagitis
Gastroesophageal Reflux
Hand
Heartburn
Hernia, Hiatal
Hoarseness
Humans
Hydrogen-Ion Concentration
Male
Prospective Studies
Proton Pump Inhibitors
Proton Pumps
Protons
Quality of Life
Surveys and Questionnaires
Risk Factors
Smoke
Smoking
Proton Pump Inhibitors
Proton Pumps
Protons
Smoke