J Menopausal Med.  2014 Dec;20(3):126-132. 10.6118/jmm.2014.20.3.126.

The Association between Serum Uric Acid Level and Incidence of Metabolic Syndrome according to Menopausal Status in Korean Women

• Joo JK
• Hong GP
• Han SE
• Lee YJ
• Kim SC
• Kim CW
• Lee KS

• KMID: 2325476
• DOI: http://doi.org/10.6118/jmm.2014.20.3.126

Abstract

OBJECTIVES
The aim of this study is to investigate the association between serum uric acid level and metabolic syndrome according to menopausal status in Korean women.
METHODS
A total of 2,241 women who visited to the health promotion center at Pusan National University Hospital from 2010 to 2014 were included in this cross-sectional study. Self-report questionnaires and interviews with healthcare providers were used to assess disease history, medication history, menstrual history and body size measuring. Anthropometric measurements and laboratory results were compared as presence of metabolic syndrome and menopausal status by student-t test. Logistic regression analysis was performed between presence of metabolic syndrome and presumable predictive factors, such as age, menopause and serum uric acid.
RESULTS
The prevalence rate of metabolic syndrome were 7.45% (63/846) in pre-menopausal group and 23.87% (333/1395) in menopausal group. Serum uric acid level was higher in menopausal women than premenopausal women (4.6 +/- 1.1 vs. 4.3 +/- 0.9. P = 0.000). And, its concentration was also higher in metabolic syndrome than normal women regarding of menopausal statue (premenopause 4.7 +/- 1.1 vs. 4.2 +/- 0.8, P = 0.001, menopause 4.9 +/- 1.3 vs. 4.5 +/- 1.0, P = 0.000). Multiple logistic regression analysis showed serum uric acid and age have relationship with metabolic syndrome (OR: 1.453, 95% confidence interval [CI]: 1.074-1.111, P = 0.000; OR: 1.092, 95% CI: 1.305-1.619, P = 0.000).
CONCLUSION
We could find out some potential of uric acid as predictive factor for metabolic syndrome in premenopausal and menopausal group. Further investigation is required to clarify the relationship between serum uric acid, menopause and metabolic syndrome.

Keyword

Menopause; Metabolic syndrome X; Uric acid

MeSH Terms

Body Size
Busan
Cross-Sectional Studies
Female
Health Personnel
Health Promotion
Humans
Incidence*
Logistic Models
Menopause
Metabolic Syndrome X
Prevalence
Surveys and Questionnaires
Uric Acid*
Uric Acid