Korean J Med.
2011 May;80(5):524-528.
Does Hyperuricemia Play a Causative Role in the Development and/or Aggravation of Renal, Cardiovascular and Metabolic Disease?
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- 1Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
Abstract
- Although an elevation of serum uric acid level is often associated with kidney disease, cardiovascular disease and metabolic syndrome, it remains controversial whether hyperuricemia per se is a true risk factor for the development or aggravation of these diseases. Recent studies have demonstrated the independent role of uric acid in progression of renal disease and the development of new-onset hypertension and diabetes. Furthermore, lowering uric acid in these patients is found to stabilize renal function and decrease cardiovascular morbidity, suggesting the causative role of uric acid in renal, cardiovascular and metabolic disease, rather than an incidental association. In this manuscript, recent understanding about the role of uric acid in the development and/or aggravation of renal, cardiovascular and metabolic diseases will be reviewed based on the results from epidemiologic, clinical and experimental studies.
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