J Lab Med Qual Assur.  2002 Dec;24(2):215-220.

Antinuclear Antibodies in Patients on Medication with Cardiovascular Drugs and Antihyperglycemic Agents

• Park PW
• Kim TY

Abstract

BACKGROUND: This study was set to determine the antinuclear antibody (ANA) frequency and fluorescence pattern, as well as the incidence of drug-induced lupus (DIL) in patients on long term medications with cardiovascular drugs and antihyperglycemic agents.
METHODS
Sera from 301 patients on medications with cardiovascular drugs or antihyperglycemic agents for at least 6 months and 105 serum samples from healthy controls were tested by indirect immunofluorescence on immunotype (IT)-1 cells, and the medical records were retrospectively reviewed. The patients included 39 on digoxin, 38 on theophylline, 8 on theophylline and digoxin, 26 on captopril, 15 on diltiazem, and 182 on antihyperlycemic agents.
RESULTS
ANA was positive in 3 of the 105 normal controls (3%). Thirty four percent of patients on medication with digoxin, 29% on theophylline, 31% on captopril, 7% on diltiazem, and 8% on antihyperglycemic agents were positive for ANA. The prominent ANA pattern was cytoplasmic type in patients on digoxin and theophylline, and the speckled type in captopril, however, most of them showed low titers.
CONCLUSIONS
Long-term ingestion of theophylline, digoxin, captopril were shown to influence ANA, but not for diltiazem and antihyperglycemics. Therefore, patients on long-term medications with theophylline, digoxin, captopril should be regularly tested for ANA.

Keyword

Antinuclear antibody; Theophylline; Digoxin; Captopril; Anti-hyperglycemic agent; Drug-induced lupus

MeSH Terms

Antibodies, Antinuclear*
Captopril
Cardiovascular Agents*
Cytoplasm
Digoxin
Diltiazem
Eating
Fluorescence
Fluorescent Antibody Technique, Indirect
Humans
Hypoglycemic Agents*
Incidence
Medical Records
Retrospective Studies
Theophylline
Antibodies, Antinuclear
Captopril
Cardiovascular Agents
Digoxin
Diltiazem
Hypoglycemic Agents
Theophylline