J Korean Acad Rehabil Med.  2004 Apr;28(2):163-168.

The Change of Bone Metabolism in Stroke Rat

• Park JH
• Ko YJ
• Kim JH
• Lee JI
• Shin JN
• Lim SH
• Im S

Abstract

OBJECTIVE
The purpose of this study was to investigate the effect of ischemic stroke on bone metabolism. METHOD: Female Sprague-Dawley rats (12 weeks old, n=48) were randomly divided into 4 separate groups; sham operation group (group A), stroke group (group B), ovariectomy group (group C), and stroke-ovariectomy group (group D). Two weeks after performing ovariectomy, cerebral ischemia was induced. The bone mineral density (BMD) and osteocalcin and carboxy-terminal telopeptide (CTX) were measured on three periods: the day before ischemia and 1 and 3 weeks post-stroke. All data were statistically analyzed. RESULTS: One week after cerebral ischemia, lumbar spine BMD of group B and D although statistically insignificant showed a lower BMD score in comparison to group A and C, respectively. Three weeks after ischemia, compared to group C, the BMD score of lumbar spine in group D was reduced significantly (p<0.05). At one week post-stroke, compared with group A and C, the value of osteocalcin in group B and D were reduced significantly, respectively (p<0.05). One and three weeks after ischemia, the CTX value in all groups showed no statistical difference. CONCLUSION: The authors concluded that ischemic stroke affected bone metabolism by decreasing osteoblastic activity in the early phase of stroke rat.

Keyword

Bone mineral density; Bone turnover marker; Osteoporosis; Rat model; Stroke

MeSH Terms

Animals
Bone Density
Brain Ischemia
Female
Humans
Ischemia
Metabolism*
Models, Animal
Osteoblasts
Osteocalcin
Osteoporosis
Ovariectomy
Rats*
Rats, Sprague-Dawley
Spine
Stroke*
Osteocalcin