J Korean Soc Spine Surg.  1998 Nov;5(2):348-352.

Eosinophilic Granuloma of the Adult Spine: Report of a Case

• Chung SS
• Lee CS
• Ahn KH
• Chung KH

Abstract

Eosinophilic granuloma of bone well-documented in the literature. This lytic bone disease most commonly occurs in children, but a fraction of the cases does occurs in adult. When the disease occurs in adults, the bone most often affected include the skull, ribs, mandible, clavicle, pelvis, and long bone of the extremities. We report the case of a 31-year old woman with isolated eosinophilic granuloma of the thoracic spine. She had a 1-month history of progressive back pain that radiated to the right anterior chest. Authors performed resection of vertebral body lesion and soft tissue lesion and anterior fusion from T7 to T9. Immunochemical staining showed a positive S100 protein stain. EM demonstrated characteristic Birbeck granule. Postoperatively, the patient underwent a 5-day course of RT to the T6-T10 spine with 200cGY fractions (total dose 1000cGY). Postoperatively, the patient's back and chest pain had disappeared. There is no evidence of local recurrence or distant metastasis at 18 months follow-up. Though rare, eosinophilic granuloma of the adult spine could be considered in the differential diagnosis of osteolytic lesions.

MeSH Terms

Adult*
Back Pain
Bone Diseases
Chest Pain
Child
Clavicle
Diagnosis, Differential
Eosinophilic Granuloma*
Eosinophils*
Extremities
Female
Follow-Up Studies
Humans
Mandible
Neoplasm Metastasis
Pelvis
Recurrence
Ribs
Skull
Spine*
Thorax