J Korean Soc Pediatr Endocrinol.  2009 Dec;14(2):163-167.

Two Cases of Slipped Capital Femoral Epiphysis in Children Receiving Growth Hormone Therapy

• Lee HS
• Yang EA
• Hong EH
• Cho MH
• Ko CW

Abstract

Slipped capital femoral epiphysis is a rare hip disorder that mainly occurs in pubertal children. Although the exact cause of this disorder is unknown, it is known to be associated with obesity, trauma, delayed sexual development, delayed bone maturation, chronic renal failure, genetic diseases, endocrine disorders (growth hormone deficiency, hypothyroidism, hypogonadism), growth hormone therapy, and gonadotropin releasing hormone agonist (GnRH agonist) therapy. We report 2 cases of slipped capital femoral epiphysis in adolescent females who were receiving growth hormone therapy. The first case is of a 16 year-old-girl with chronic renal failure and renal osteodystrophy. The second case is of an 11 year-old-girl with idiopathic precocious puberty who had received GnRH agonist and growth hormone therapy. Unilateral or bilateral slipped capital femoral epiphysis developed at 1 year 3 months after treatment in both the cases. The chief complaints were pain in the hip joint and lower extremities. Growth hormone and/or GnRH agonist therapy was stopped, and in situ screw fixations of the involved hip epiphyses were performed.

Keyword

Slipped epiphysis; Growth hormone

MeSH Terms

Adolescent
Child
Endocrine System Diseases
Epiphyses
Female
Gonadotropin-Releasing Hormone
Growth Hormone
Hip
Hip Joint
Humans
Hypothyroidism
Kidney Failure, Chronic
Lower Extremity
Obesity
Puberty, Precocious
Renal Osteodystrophy
Sexual Development
Slipped Capital Femoral Epiphyses
Gonadotropin-Releasing Hormone
Growth Hormone