J Korean Soc Menopause.  2013 Aug;19(2):81-86.

Association between Serum Homocysteine Concentrations and Bone Mineral Density in Middle Aged Women

• Kim A
• Lee JH
• Lee JY
• Oh YM
• Hong SN
• Choi H
• Jae EA
• Lee HH
• Kim HY

Abstract

OBJECTIVES
Hyperhomocysteinemia is known to be related with the early onset of osteoporosis. This study was to examine the association between serem homocysteine levels and bone mineral density (BMD) in middle aged women.
METHODS
The study included 409 women who underwent bone density tests in the health screening centers from January 2009 to october 2010. Serum homocysteine levels and BMD were measured.
RESULTS
Postmenopause group (n = 109) showed significantly lower BMD score in lumbar spine and femoral neck and significantly higher serum homocysteine concentration compared to premenopause group (n = 300). However, after adjusting for age, body mass index, and the menopausal condition in total 409 women, there were no significant correlations between serum homocysteine levels and BMD.
CONCLUSION
Measurement of serum homocysteine levels may not be useful, but adjunctive for the risk assessment of osteoporosis in middle aged women.

Keyword

Bone density; Homocysteine; Osteoporosis

MeSH Terms

Body Mass Index
Bone Density
Female
Femur Neck
Homocysteine
Humans
Hyperhomocysteinemia
Mass Screening
Middle Aged
Osteoporosis
Postmenopause
Premenopause
Risk Assessment
Spine
Homocysteine

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