J Korean Soc Menopause.  2013 Aug;19(2):81-86.

Association between Serum Homocysteine Concentrations and Bone Mineral Density in Middle Aged Women

Affiliations
  • 1Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea.
  • 2Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
  • 3Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea. hykyale@yahoo.com, 5788421@hanmail.net
  • 4Department of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • 5Department of Obstetrics and Gynecology, College of Medicine, Inje University, Seoul, Korea.
  • 6Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Abstract


OBJECTIVES
Hyperhomocysteinemia is known to be related with the early onset of osteoporosis. This study was to examine the association between serem homocysteine levels and bone mineral density (BMD) in middle aged women.
METHODS
The study included 409 women who underwent bone density tests in the health screening centers from January 2009 to october 2010. Serum homocysteine levels and BMD were measured.
RESULTS
Postmenopause group (n = 109) showed significantly lower BMD score in lumbar spine and femoral neck and significantly higher serum homocysteine concentration compared to premenopause group (n = 300). However, after adjusting for age, body mass index, and the menopausal condition in total 409 women, there were no significant correlations between serum homocysteine levels and BMD.
CONCLUSION
Measurement of serum homocysteine levels may not be useful, but adjunctive for the risk assessment of osteoporosis in middle aged women.

Keyword

Bone density; Homocysteine; Osteoporosis

MeSH Terms

Body Mass Index
Bone Density
Female
Femur Neck
Homocysteine
Humans
Hyperhomocysteinemia
Mass Screening
Middle Aged
Osteoporosis
Postmenopause
Premenopause
Risk Assessment
Spine
Homocysteine

Reference

1. El Maghraoui A, Koumba BA, Jroundi I, Achemlal L, Bezza A, Tazi MA. Epidemiology of hip fractures in 2002 in Rabat, Morocco. Osteoporos Int. 2005; 16:597–602.
2. Lentle BC, Brown JP, Khan A, Leslie WD, Levesque J, Lyons DJ, et al. Recognizing and reporting vertebral fractures: reducing the risk of future osteoporotic fractures. Can Assoc Radiol J. 2007; 58:27–36.
3. Durand P, Prost M, Loreau N, Lussier-Cacan S, Blache D. Impaired homocysteine metabolism and atherothrombotic disease. Lab Invest. 2001; 81:645–672.
4. McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med. 2004; 350:2042–2049.
5. Ozdem S, Samanci S, Tasatargil A, Yildiz A, Sadan G, Donmez L, et al. Experimental hyperhomocysteinemia disturbs bone metabolism in rats. Scand J Clin Lab Invest. 2007; 67:748–756.
6. Tyagi N, Kandel M, Munjal C, Qipshidze N, Vacek JC, Pushpakumar SB, et al. Homocysteine mediated decrease in bone blood flow and remodeling: role of folic acid. J Orthop Res. 2011; 29:1511–1516.
7. Kusano K, Miyaura C, Inada M, Tamura T, Ito A, Nagase H, et al. Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption. Endocrinology. 1998; 139:1338–1345.
8. Banfi G, Iorio EL, Corsi MM. Oxidative stress, free radicals and bone remodeling. Clin Chem Lab Med. 2008; 46:1550–1555.
9. Weiss N, Heydrick S, Zhang YY, Bierl C, Cap A, Loscalzo J. Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice. Arterioscler Thromb Vasc Biol. 2002; 22:34–41.
10. Morris MS, Jacques PF, Selhub J. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone. 2005; 37:234–242.
11. Gerdhem P, Ivaska KK, Isaksson A, Pettersson K, Vaananen HK, Obrant KJ, et al. Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women. J Bone Miner Res. 2007; 22:127–134.
12. Yilmaz N, Kepkep N, Ciçek HK, Celik A, Meram I. Relation of parity and homocysteine to bone mineral density of postmenopausal women. Clin Lab. 2006; 52:49–56.
13. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, van der Klift M, de Jonge R, Lindemans J, et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med. 2004; 350:2033–2041.
14. Browner WS, Malinow MR. Homocyst(e)inaemia and bone density in elderly women. Lancet. 1991; 338:1470.
15. Cagnacci A, Baldassari F, Rivolta G, Arangino S, Volpe A. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women. Bone. 2003; 33:956–959.
16. Rasmussen K, Møller J. Total homocysteine measurement in clinical practice. Ann Clin Biochem. 2000; 37(Pt 5):627–648.
17. Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C. Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr. 1999; 70:904–910.
18. Cravo ML, Glória LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, et al. Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status. Am J Clin Nutr. 1996; 63:220–224.
19. Grant SF, Reid DM, Blake G, Herd R, Fogelman I, Ralston SH. Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nat Genet. 1996; 14:203–205.
20. Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, et al. A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study. J Bone Miner Res. 2003; 18:723–729.
21. Kim TH, Lee HH, Chung SH, Park HS. Differentiation in the management of osteoporosis between premenopausal and menopausal women. J Korean Soc Menopause. 2011; 17:21–26.
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