World J Mens Health.  2013 Aug;31(2):141-149.

Effects of Sesame Oil on the Reproductive Parameters of Diabetes Mellitus-Induced Male Rats

• Abbasi Z
• Tabatabaei SRF
• Mazaheri Y
• Barati F
• Morovvati

Abstract

PURPOSE
The purpose of the present study was to investigate the effect of sesame oil on the reproductive parameters of diabetic male Wistar rats.
MATERIALS AND METHODS
The adult male rats in a split plot design were divided into normal (n=10), normal 5% (n=5; 5% sesame oil enriched diet), diabetic (Streptozocin induced diabetes; n=9), diabetic 5% (n=9; 5% sesame oil enriched diet), and diabetic 10% (n=9; 10% sesame oil enriched diet) groups. Diet supplementation continued for 56 days.
RESULTS
Sesame oil supplementation did not reduce the plasma glucose concentration of rats in the diabetic groups (p>0.05). The total spermatogonia, spermatocytes, Leydig cells/tubule, and the germ cell to Sertoli cell ratio were lower in the diabetic rats than the normal ones (p<0.05), and with the exception of spermatogonia counts, these values improved by the addition of sesame oil to the diet (p<0.05). The sperm progressive motility and viability were lower in the diabetic rats (p<0.05) and sesame oil supplementation did not improve them. Incorporation of sesame oil into the diet improved the plasma testosterone concentration of the diabetic rats in a dose-dependent manner (p<0.05).
CONCLUSIONS
In summary, sesame oil supplementation improved the reproductive parameters of diabetic rats at the levels of the testicular microstructure and function, but was not effective in protecting the epididymal sperm.

Keyword

Rats; Diabetes mellitus; Spermatozoa; Testis; Testosterone; Sesame oil

MeSH Terms

Adult
Animals
Diabetes Mellitus
Diet
Germ Cells
Male
Rats
Sesame Oil
Sesamum
Spermatocytes
Spermatogonia
Spermatozoa
Testis
Testosterone
Sesame Oil
Testosterone

Figure

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  Fig. 1 Microscopic views of testicular sections of different groups stained with H&E (magnification: ×20): Normal (A), diabetic (B), normal with 5% sesame oil (C), diabetic receiving 5% sesame oil (D), and diabetic receiving 10% sesame oil (E).

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