Tuberc Respir Dis.  2015 Oct;78(4):385-389. 10.4046/trd.2015.78.4.385.

Single Nodular Pulmonary Amyloidosis: Case Report

• Lee SH
• Ko YC
• Jeong JP
• Park CW
• Seo SH
• Kim JT
• Park DW
• Bak CM
• Moon SK
• Jo SH
• Kim SM
• Jung AL

• KMID: 2320712
• DOI: http://doi.org/10.4046/trd.2015.78.4.385

Abstract

Amyloidosis is defined as the presence of extra-cellular deposits of an insoluble fibrillar protein, amyloid. The pulmonary involvement of amyloidosis is usually classified as tracheobronchial, parenchymal nodular, or diffuse alveolar septal. A single nodular lesion can mimic various conditions, including malignancy, pulmonary tuberculosis, and fungal infection. To date, only one case of nodular pulmonary amyloidosis has been reported in Korea, a case involving multiple nodular lesions. Here, we report and discuss the case of a patient having single nodular amyloidosis.

Keyword

Amyloidosis

MeSH Terms

Amyloid
Amyloidosis*
Humans
Korea
Tuberculosis, Pulmonary
Amyloid

Figure

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  Figure 1 Simple chest radiography showing a nodular lesion in the right upper lobe inferior margin near the hilum.

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  Figure 2 (A, B) Chest computed tomography showing an approximately 1.8-cm subpleural nodular consolidation with some spiculation in the inferior margin of the right upper lobe (arrowheads).

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  Figure 3 Histopathological examination of the nodule showing eosinophilic, amorphous material deposits (H&E stain, ×100).

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  Figure 4 The nodule shows an apple-green birefringence, that is regarded as diagnostic (Congo red staining, as seen under a polarized microscope, ×100).

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  Figure 5 Normal serum protein electrophoresis (EP) results. SPE: serum protein electrophoresis.

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