Tuberc Respir Dis.  2015 Jul;78(3):203-209. 10.4046/trd.2015.78.3.203.

Efficacy of Induced Sputum for the Diagnosis of Pulmonary Tuberculosis in Adults Unable to Expectorate Sputum

• Park JS

• KMID: 2320644
• DOI: http://doi.org/10.4046/trd.2015.78.3.203

Abstract

BACKGROUND
Induced sputum (IS) has been used to collect airway secretions in subjects who have inadequate sputum production. The aim of this study was to investigate the efficacy of IS for the diagnosis of pulmonary tuberculosis (PTB) in adults unable to expectorate sputum.
METHODS
Medical records of 39 PTB patients who underwent IS due to absence of spontaneous sputum production between January 2011 and March 2014 at a tertiary hospital in South Korea were reviewed. Results of acid fast bacilli smear, Mycobacterium tuberculosis culture and polymerase chain reaction assay for M. tuberculosis (TB-PCR) of IS specimens from these patients were analyzed. Clinical and high-resolution computed tomography (HRCT) characteristics were also analyzed to find characteristics associated with IS culture positivity.
RESULTS
Of the 39 IS specimens from PTB patients, 7 (17.9%) were smear positive and 31 (79.5%) were culture positive. Twenty-four IS specimens were tested for TB-PCR and 13 (54.2%) were positive on TB-PCR. Multivariate analysis showed that younger age (p=0.04) and presence of tree-in-bud appearance on HRCT (p=0.03) were independent predictors of IS culture positivity.
CONCLUSION
IS is useful for the diagnosis of PTB in adults unable to expectorate sputum. Younger age and tree-in-bud appearance on HRCT were associated with IS culture positivity in these patients.

Keyword

Tuberculosis, Pulmonary; Sputum, Induced; Tomography; Diagnosis

MeSH Terms

Adult*
Diagnosis*
Humans
Korea
Medical Records
Methods
Multivariate Analysis
Mycobacterium tuberculosis
Polymerase Chain Reaction
Sputum*
Tertiary Care Centers
Tuberculosis
Tuberculosis, Pulmonary*

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