Tuberc Respir Dis.  2014 Apr;76(4):184-187.

Single Pleural Relapse of a Nasal-Type Extranodal Natural Killer/T-Cell Lymphoma: A Case Report

• Kim K
• Oh Y
• Lim SN
• Choi SY
• Lee OJ
• Choe KH
• Lee KM
• An JY

Abstract

A nasal-type extranodal natural killer/T-cell lymphoma is considered an aggressive form of non-Hodgkin's lymphoma, with approximately half of all patients relapsing during the follow-up period, and most relapses occurring within the first 2 years of remission. Here we report an unusual case of a 42-year-old man who experienced recurrence in single pleura after 8 years of remission.

Keyword

Pleural Effusion; Adenosine Deaminase; Lymphoma, Extranodal NK-T-Cell

MeSH Terms

Adenosine Deaminase
Adult
Follow-Up Studies
Humans
Lymphoma*
Lymphoma, Extranodal NK-T-Cell
Lymphoma, Non-Hodgkin
Pleura
Pleural Effusion
Recurrence*
Adenosine Deaminase

Figure

• 

  Figure 1 (A) A chest radiograph showing costophrenic angle blunting, consistent with a small amount of pleural effusion. (B) A chest computed tomography (CT) scan showing an enhanced heterogeneous mass-like lesion in the left eight paravetebral area. (C) 18F-fluorodeoxyglucose (FDG)-positron-emission tomography revealed an intense FDG uptake at the same site as on the CT.

• 

  Figure 2 Pleural involvement of extranodal natural killer/T-cell lymphoma, nasal type. (A) Atypical lymphocytes of small to medium size are diffusely infiltrated in pleural tissue (H&E stain, ×200). (B) The infiltrate shows an angiocentric growth pattern (H&E stain, ×200). (C-E) The neoplastic cells shows positive reactivity for CD3 (C, ×200), CD56 (D, ×200), and granzyme B (E, ×200) by immunohistochemical staining. (F) Epstein-Barr virus in situ hybridization reveals nuclear positivity blue color (×200). (G) The initial biopsy from the nasal cavity showed proliferation of atypical lymphoid cells with extensive necrosis (asterisk), angiocentric growth pattern (arrows) and mild pleomorphism (H&E stain, ×200). (H) The neoplastic cells revealed immunoreactivity for CD56 antibody (×200).

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