Yeungnam Univ J Med.  1998 Dec;15(2):350-358.

A case of primary antiphospholipid antibody syndrome showing vegetation on the mitral valve through echocardiography

• Lee SY
• Park SK
• Yun SH
• Jung YS
• Kim HJ
• Lim SH
• Hah JS
• Kim WN

Abstract

Antiphospholipid antibody syndrome(APS) is a well-known clinical syndrome characterized by recurrent arterial or venous thromboses, recurrent fetal loss, thrombocytopenia, together with high titers of sustained anticardiolipin antibody(aCL) or lupus anticoagulant(LA). Although systemic lupus erythematosus(SLE) and APS may coexist, a high proportion of patients manifesting the APS do not suffer from classical lupus or other connective tissue disease. The patient has been defined as having a primary antiphospholipid antibody syndrome. We experienced one case of primary APS with recurrent fetal loss, recurrent cerebral infarctions, positive anticardiolipin antibody IgG and fluttering vegetation on the mitral valve, without other connective tissue diseases including SLE. Forty-three old female had 2 out of 11 criteria for the diagnosis of SLE, such as thrombocytopenia and positive antinuclear antibody, but did not meet whole criteria. The patient was treated with ticlopidine, and anticoagulant therapy was recommended.

Keyword

Antiphospholipid antibody syndrome; Cerebral infarction

MeSH Terms

Antibodies, Anticardiolipin
Antibodies, Antinuclear
Antibodies, Antiphospholipid*
Antiphospholipid Syndrome*
Cerebral Infarction
Connective Tissue Diseases
Diagnosis
Echocardiography*
Female
Humans
Immunoglobulin G
Mitral Valve*
Thrombocytopenia
Ticlopidine
Venous Thrombosis
Antibodies, Anticardiolipin
Antibodies, Antinuclear
Antibodies, Antiphospholipid
Immunoglobulin G
Ticlopidine