Yeungnam Univ J Med.  1999 Dec;16(2):270-276.

Detection Rate of Extended-Spectrum beta-Lactamase Producers in Klebsiella pneumoniae and Escherichia coli Isolated at Yeungnam University Medical Center

• Lee CH
• Lee HC
• Kim KD
• Lee TS

Abstract

BACKGROUND: Extended-spectrum beta-lactamases(ESBL) are enzymes that confer resistance to oxyimino-beta-lactams as well as to penicillins and cephalosporins. Strains of Klebsiella pneumoniae and Escherichia coli that produce ESBL have been increasingly prevalent in many countries. The purpose of this study was to investigate the ESBL production rate of K. pneumoniae and E. coli at the in Yeungnam University Medical Center.
MATERIALS AND METHODS
Thirty-one isolates of K. pneumoniae and twenty-five isolates of E. coli were examined for ESBL by double disk synergy test, using 20/10microgram ticarcillin/clavulanic acid and 30microgram oxymino-beta-lactam(ceftazidime, ceftriaxone and aztreonam) disks.
RESULTS
Fifty-two percent of K. pneumoniae and sixteen percent of E. coli isolates revealed double disk synersism. Majority of ESBL-producing strains(fifty-five percent) were isolated from patients in the intensive care unit.
CONCLUSION
ESBL production of K. pneumoniae and E. coli were also common at the Yeungnam Univercity Medical Center and pose a serious problem for antimicrobial therapy.

Keyword

Extended-spectrum beta-lactamases; Investigate

MeSH Terms

Academic Medical Centers*
beta-Lactamases*
Ceftriaxone
Cephalosporins
Escherichia coli*
Escherichia*
Humans
Intensive Care Units
Klebsiella pneumoniae*
Klebsiella*
Penicillins
Pneumonia
Ceftriaxone
Cephalosporins
Penicillins
beta-Lactamases