Yeungnam Univ J Med.  1999 Dec;16(2):219-227.

The Clinical Effects of Cefpirome for the Treatment of Acute Lower Respiratory Infection

• Shin KC
• Hong YH
• Lee EY
• Park KD
• Kim SD
• Chung JH
• Lee CK
• Lee KH
• Sung CK
• Lee HW

Abstract

BACKGROUND: In contrast to a healthy person, patients who have acute lower pespiratory tract infection with underlying pulmonary diseases have various pathogens, a rapidly progressie downhill course, and a poor response to prior antimicrobial therapy. Broad spectrum antivacterial therapy is needed for full evaluation.
MATERIALS AND METHODS
To evaluate the efficacy and safety of cefpirome, we administered 1gm cefpirome, twice a day to 30 patients who had signs and symptoms of acute lower repiratory infection regardless of their underlying disease, except to those who had an allergic history to antibiotics or severe systemic diseases.
RESULTS
The results were as follows : 1) Among 30 cases, 21 cases(70.0%) showed excellent improvement, and 7 cases(23.3%) showed good improvement in their symptoms and signs of acute lower respiratory infection. 2) In 14 cases with isolated pathogens, we observed bacteriologic eradication in 11 cases(78.6%). 3) Significant side effects were not found
CONCLUSION
Above results suggest that cefpirome was effective as a monotherapy in patients with acute lower respriatory infection, especially on those with as underlying chronic obstructive pulmonary disease(COPD).

Keyword

Cefpirome; Acute lower respiratory infection; COPD

MeSH Terms

Anti-Bacterial Agents
Humans
Lung Diseases
Pulmonary Disease, Chronic Obstructive
Anti-Bacterial Agents